Ursolic Acid

Ursolic acid (CAS No.: 77-52-1), pure plant extract, is a triterpenoid compound that exists in natural plants. It has sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lower blood sugar And other biological effects, ursolic acid also has obvious antioxidant function, so it is widely used as a raw material for medicine and cosmetics.

The clinical manifestations of ursolic acid can significantly and rapidly reduce alanine aminotransferase, serum aminotransferase, reduce jaundice, increase appetite, anti-fibrosis, and restore liver function. It has the characteristics of quick effect, short course of treatment and stable effect.

Ursolic acid is also resistant to a variety of carcinogens and carcinogens. Studies have found that ursolic acid can significantly inhibit the proliferation of HL-60 cells and induce their apoptosis; it can significantly improve the phagocytic function of macrophages in mice. It can inhibit the proliferation of human tongue squamous carcinoma cell line TSCCa, and the inhibitory amount for half of the growth of TSCCa cells is about 12.5 μmol•L-1, which shows a certain dose-effect relationship within 24 hours; in situ hybridization shows that ursolic acid has an effect on TSCCa. The inhibitory effect of cells is related to the inhibition of the in situ expression of nuclear transcription factors. . In vivo experiments have proved that ursolic acid can significantly enhance the immune function of the body. It shows that ursolic acid has a wide range of anti-tumor effects, and ursolic acid is very likely to become a new type of low-toxicity and effective anti-cancer drug.

Ursolic acid is a strong antioxidant. Experiments have shown that ursolic acid can inhibit the activities of 5-lipoxygenase and cyclooxygenase during the metabolism of arachidonic acid, and prevent the production of prostaglandins and leukotrienes. This may be because ursolic acid inhibits inflammation and inhibits lipid metabolism. The cause of oxide. Subbaramaiah and other studies have shown that ursolic acid can inhibit the transcription of cyclooxygenase in human breast epithelial cells, thereby inhibiting prostaglandin production.