Best Trifluoroacetic Anhydride CAS 407-25-0

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Trifluoroacetic Anhydride

Products Description

Name: Trifluoroacetic Anhydride

Cas: 407-25-0

Purity: 99%min


Basic Info:

CAS No.:






Stock Availability

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Brand Name

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Product Introduction:

Trifluoroacetic anhydride (TFAA) is a colorless and transparent liquid with a pungent odor, volatile, and the molecular formula is C4F6O3.

Trifluoroacetic Anhydride is a colorless volatile liquid in general state, hygroscopic, decomposed in water and ethanol, soluble in ether and acetic acid.

Trifluoroacetic anhydride is a representative strong dehydrating agent with a wide range of chemical reactivity.

It is usually refluxed with phosphorus pentoxide and purified by distillation before use.

Because there are two strong electron-withdrawing groups, trifluoromethyl, in its structure, it is a relatively strong organic acid anhydride, and its chemical properties are relatively active. Therefore, trifluoroacetic anhydride has a great use in organic synthesis.

Product Nature:

  • Density: 1.511 g/mL at 20 °C(lit.)
  • Boiling point: 39.5-40 °C(lit.)
  • Melting point: -63.5 °C
  • Flash point: -26 °C
  • Refractive index: n20/D 1.3(lit.)
  • Water solubility: Hydrolysis
  • Vapor Pressure: 439mmHg at 25°C


Product NameTrifluoroacetic Anhydride
CAS No.407-25-0
Appearance Colorless transparent liquid
Content99% min
Shelf Life2 years
Packing1kgs/drum,25kgs/drum or as your requirements

Product Usage:

Trifluoroacetic anhydride is a commonly used reagent in chemical laboratories and is often used as an analytical reagent, solvent, catalyst, dehydration condensing agent, and protective agent for carboxyl and amino trifluoroacetylation.

Trifluoroacetic Anhydride is a raw material for preparing organic fluorine fine chemicals, medicines, pesticides, and new liquid crystal materials.

It is used as solvent, catalyst, dehydration condensing agent and retaining agent in the synthesis of various polymers and fine chemicals.

It is also widely used in dyes, photosensitive materials, liquid crystal display materials, aerospace technology, pesticides, medicine, polymer materials, etc.

Trifluoroacetic anhydride can react with carboxylic acid to form the corresponding mixed acid anhydride (i.e. activated ester), which enhances the electrophilicity of the carbonyl group of the carboxylic acid and makes it more difficult to be attacked by nucleophiles.

In the presence of a weak base, trifluoroacetic anhydride can be used as a dehydrating agent to dehydrate amides, oximes, hydroxy ketones or hydroxy acid esters to generate corresponding nitriles, unsaturated ketones or carboxylic acid esters.

The trifluoroacetyldimethylsulfonium salt of trifluoroacetic acid is a kind of very effective oxidant, which can oxidize alcohol to the corresponding carbonyl compound in high yield, and the oxidizing reagent is also relatively stable to halogenated hydrocarbons, which has many advantages.

It can improve the speed of the polymerization reaction and the yield of the product, and can be used as a derivatized chemical reagent in the detection of toxic metabolites and mycotoxins in livestock meat, fruits and vegetables by gas chromatography and high performance liquid chromatography, and has a very good development and application prospect.


  1. On the Purification of Laboratory Chemicals” – Google Books excerpt | 2003 – 609 pages.
  2. Trifluoroacetic anhydride: a new reagent for the oxidation of alcohols to carbonyl compounds” – Kanji Omura, Ashok K. Sharma, and Daniel Swern | March 1, 1976.
  3. Wikipedia


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1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).

2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).

3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).

4. For high-value products, please choose air or express to ensure the safety of product transportation.


Do you accept sample order?

We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.

How to confirm whether the product quality meets our needs before placing an order?

You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.

What’s your MOQ?

Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

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Trifluoroacetic Anhydride