Trifluoroacetic Anhydride CAS 407-25-0

Zinc sulphate monohydrate
Zinc Sulphate Monohydrate CAS 7446-19-7
Trifluoroacetic Anhydride

Products Description

Name: Trifluoroacetic Anhydride

Cas: 407-25-0

Purity: 99%min


Product Parameters:

CAS Number:407-25-0
Molecular formula:C4F6O3
Molecular weight:210
EINECS Number:206-982-9
Octanol/water partition coefficient:0.25
Properties:Colorless liquid with pungent odor, volatile.
Refractive index:n20/D 1.3 (dots)
Surface tension (dyne/cm):19.3
Synonyms:trifluoroacetic acid anhydride, trifluoroacetic anhydride, TFAA
Relative vapor density (air=1):3.9
Relative density (water=1):1.49 (25℃)
Boiling point (℃):39.5~40.1
Melting point (℃):-65
Flash point:-26 °C
Isotonic specific volume (90.2K):268.3
Polarizability (10-24cm3):9.23


Item Specification
Properties: Colorless liquid
Brand: Look Chemical
MDL number: MFCD00000416
SKU: LC-407-25-0
Origin: China
Purity: 99% min
Packing 1kgs/drum,25kgs/drum or as your requirements
MSDS: Yes, COA: Yes

Definition of Trifluoroacetic Anhydride:

Trifluoroacetic anhydride (TFAA) is the acid anhydride of trifluoroacetic acid, an organic compound with the molecular formula C4F6O3.

The colorless volatile liquid in general state, hygroscopic, decomposed in water and ethanol, soluble in ether and acetic acid. It is a representative strong dehydrating agent with broad chemical reactivity.

It has a wide range of chemical reactivity. It is mainly used as an analytical reagent, solvent, catalyst, dehydration condensation agent, carboxyl, and amino trifluoroacetylation protective agent to synthesize various polymers and fine chemicals.

In addition, it is also widely used in dyes, photosensitive materials, liquid crystal display materials, aerospace technology, pesticides, medicine, polymer materials, etc.

Product Usage:

Trifluoroacetic anhydride is a commonly used reagent in chemical laboratories. Main application: used as analytical reagent, solvent, catalyst, dehydration condensing agent, and protective agent for carboxyl and amino trifluoroacetylation.

  • Trifluoroacetic anhydride is hygroscopic and can be used as a dehydrating reagent for some reactions.
  • A mixture of it and sodium iodide can be used as a reducing agent.
  • A mixture of it and dimethyl sulfoxide can be used as an oxidant.
  • It is the raw material for preparing organic fluorine fine chemicals, medicines, pesticides, and new liquid crystal materials.
  • Gas Chromatographic Analysis of Biologically Active Compounds.
  • It can be used as a protective agent for primary and secondary amines.
  • Trifluoroacetic anhydride is also used to oxidize aldehydes to acids, esters, and amines.

It is also widely used in dyes, photosensitive materials, liquid crystal display materials, aerospace technology, pesticides, medicine, polymer materials, etc.

Chemical Properties:

Trifluoroacetic anhydride reacts with carboxylic acid to form the corresponding mixed acid anhydride (i.e., activated ester), which enhances the electrophilicity of the carboxylic acid carbonyl group and makes it more difficult to be attacked by nucleophiles.

In a weak base, trifluoroacetic anhydride can be used as a dehydrating agent to dehydrate amides, oximes, hydroxy ketones, or hydroxy esters to generate the corresponding nitriles, unsaturated ketones or carboxylic acid esters.

Trifluoroacetyldimethylsulfonium salt of trifluoroacetic acid is a very effective oxidant, which can oxidize alcohols to corresponding carbonyl compounds in high yield, and the oxidant is also relatively stable to halogenated hydrocarbons, which has many advantages.

It can improve the speed of the polymerization reaction and the product yield. Gas and high-performance liquid chromatography can be used as a derivatized chemical reagent for detecting toxic metabolites and mycotoxins in livestock meat, fruits, and vegetables. Has very good development and application prospects.

Our Factory and Equipment:

As an experienced trifluoroacetic anhydride manufacturer, supplier, Look Chemical is committed to manufacturing and selling high quality trifluoroacetic anhydride.

Our factory has first-class production equipment and production lines to ensure the stability of product supply. At the same time, we can produce trifluoroacetic anhydride products of different specifications according to the customer’s market demand to ensure that the product content and quality meet customer needs.

If you have a demand for this product or its related products, please contact our company’s service personnel, and we will provide you with a solution in the shortest possible time.

Product Data:

1. Certificate Of Analysis (COA)

2. Material Safety Data Sheet (MSDS)

3. Route of synthesis (ROS)

4. Method of Aanlysis (MOA)

5. Nuclear Magnetic Resonance (NMR)

6. Packing pictures and loading video before loading

7. Free Sample

8. Factory audit


  1. On the Purification of Laboratory Chemicals” – Google Books excerpt | 2003 – 609 pages.
  2. Trifluoroacetic anhydride: a new reagent for the oxidation of alcohols to carbonyl compounds” – Kanji Omura, Ashok K. Sharma, and Daniel Swern | March 1, 1976.
  3. Wikipedia


Pre-Sales Service

* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.

* The sample supports testing and inspection.

* Each batch of products will be tested to ensure that its quality meets user needs.

*Packaging can also be made according to customer requirements.

*Any inquiries will be answered by our relevant personnel within 24 hours.

*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.


After-Sales Service

*We will monitor the logistics information in real time and will share the information with you.

* You can consult us at any time if you have any questions about the product, and we will answer you in time.

*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.


1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).

2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).

3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).

4. For high-value products, please choose air or express to ensure the safety of product transportation.


Do you accept sample order?

We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.

How to confirm whether the product quality meets our needs before placing an order?

You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.

What’s your MOQ?

Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Learn more about us

Contact us for the latest quotation and free samples of Trifluoroacetic Anhydride.

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Packaging and shipping

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Trifluoroacetic Anhydride