Triflic Acid, also known as trifluoromethanesulfonic acid, is a strong organic acid with the molecular formula CF3SO3H, easily soluble in water and low in toxicity.
It is a hygroscopic colorless liquid at room temperature, yellow or yellow-brown liquid when it contains impurities, and fumes in the air.
Triflic Acid is one of the known super acids. Because of its strong thermal and chemical stability, it and its conjugate base have many uses.
Triflic Acid also does not easily sulfonate other substances, so there is no need to worry about this reaction as when using sulfuric acid, fluorosulfuric acid and chlorosulfonic acid.
However, the rapid addition of Trifluoromethanesulfonic Acid to polar solvents can be dangerous due to the highly exothermic dissolution process of Trifluoromethanesulfonic Acid.
Therefore, the reagent should be stored in disposable vials or teflon bottles, and should be used in a fume hood.
Triflic Acid has a vast array of uses. It is the greatest well-known natural acid as well as a flexible artificial device.
Triflic Acid is hygroscopic and also highly corrosive, as well as is extensively utilized in pharmaceutical, chemical and also other markets.
Such as nucleosides, antibiotics, steroids, proteins, glycosides, vitamin synthesis, silicone rubber modification, etc.
Triflic Acid has the features of tiny dosage, solid acidity and also stable residential properties.
It can change typical not natural acids such as sulfuric acid and also hydrochloric acid in lots of events, and contribute in improving the process as well as maximizing.
Triflic Acid can also be used as a stimulant for isomerization as well as alkylation.
Trifluoromethanesulfonic acid can also be used to prepare 2,3-dihydro-2-indanone, tetralone, as well as can likewise eliminate glycosides in glycoproteins, etc.
Trifluoromethanesulfonic acid is an organic solid acid commonly made use of in labs. It can be used to prepare trifluoromethanesulfonic anhydride and also numerous trifluoromethanesulfonic acid by-products. Trifluoromethanesulfonic acid is additionally an alkene and ether oligomer as well as Reliable stimulant for polymerization.
Trifluoromethanesulfonic acid (TfOH) fumes in the air and easily absorbs water to form a monohydrate.
Triflic Acid is very soluble in water, and the melted water releases a lot of heat and hydrolyzes to generate trifluoromethane (CHF3) and sulfuric acid.
Trifluoromethanesulfonic acid (TfOH) can react with phosphorus pentoxide under heating to obtain trifluoromethanesulfonic anhydride (similarly, concentrated sulfuric acid and phosphorus pentoxide react to obtain sulfur trioxide).
In the laboratory, trifluoromethanesulfonic acid is commonly used in protonation reactions because its conjugate base is non-nucleophilic.
Triflic Acid is also used for anhydrous acid-base titration, because it can show strong acidity in many non-aqueous solvents (such as glacial acetic acid, acetonitrile, etc.).
However, common inorganic strong acids, such as hydrogen chloride or sulfuric acid, only show moderate acidity in organic solvents.
Many strong acids, such as perchloric acid or nitric acid, have strong oxidizing properties.
However, neither trifluoromethanesulfonic acid nor its conjugate base, CF3SO3−, (triflate), undergoes oxidation or reduction reactions.
When using sulfuric acid, fluorinated sulfuric acid, or chlorosulfonic acid, the solvent may be sulfonated.
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