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Tranylcypromine Hemisulfate
Tranylcypromine Hemisulfate

Products Description

Name: Tranylcypromine Hemisulfate

Cas: 13492-01-8

Purity: 99%min

MOQ: 1KG

Basic Info:

CAS No.:

13492-01-8

Formula:

C18h24n2o4s

EINECS:

236-807-1

Type:

Synthesis Material Intermediates

Appearance:

Liquid

Quality:

Industrial

Colour

Colorless

 

Certificate

ISO 9001

Sample

Available

Supply Type

OEM/ODM

Brand Name

look chemical

Transport Package

100g; 1kg; 25g

Specification

free sample

Origin

China

 

Application:

Tranylcypromine hemisulfate is an irreversible, non-selective MAO inhibitor used to treat depression.

Mainly used in the research and development of anti-cancer drugs, anti-depression, etc.
Content above 99

Specification:

ItemSpecification
Product NameTranylcypromine Hemisulfate
CAS No.13492-01-8
Appearance Colorless liquid
Content99% min
Loss on drying0.1% max
UsageMedical intermediate

Product research:

In vitro studies:

Tranylcypromine (10 nM to 10 μM) exerts neuroprotective effects against human Aβ(1-42) oligomer-induced toxicity independent of the presence of glial cells.

Tranylcypromine (100μM) significantly protects RGCs from apoptosis induced by glutamate neurotoxicity and apoptosis induced by oxidative stress.

Under glutamate (Glu)-induced stress conditions, Tranylcypromine stimulates the expression of mitogen-activated protein kinase 12 (p38MAPKγ). In addition, tranylcypromine contributes to the survival of RGCs by altering the activity of p38MAPKγ.

In vivo studies

In mice that induced endometriosis, Tranylcypromine treatment significantly and significantly reduced the size of the lesions and improved systemic hyperalgesia in a dose-dependent manner.

In addition, tranylcypromine treatment resulted in decreased immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to EMT and stagnation of lesion growth.

Tranylcypromine (500 mM) injection exerts a neuroprotective effect in the intracellular apoptosis signaling pathway, inhibits the morphological changes of the rat retina, inhibits the activity of caspase 3, restores the expression of p38MAPKγ in the retina after NMDA-induced injury, and enhances the RGC after retinal injury The survival rate is reduced by NMDA neurotoxicity.

As detected by BrdU immunohistochemistry, Tranylcypromine (10 μg/g) resulted in an approximate and significant doubling of the labeled cells in the combined brain regions examined. Tranylcypromine causes the greatest increase in cerebellar cell proliferation.

Animal experiment:

Briefly, rats were anesthetized by intraperitoneal injection of a 1:1 mixture of xylazine hydrochloride (4 mg/kg) and ketamine hydrochloride (10 mg/kg).

The pupils were then dilated with phenylephrine hydrochloride and tropicamide eye drops and 20 nmol NMDA with or without tranylcypromine was injected into the vitreous cavity.

To evaluate the inhibitory effect of mitogen-activated protein kinase (MAPK), 100 nmol of BIRB796 was intravitreally injected simultaneously with NMDA injection.

Inject under the microscope using a 33-gauge needle connected to a microsyringe and insert a needle approximately 1.0 mm behind the corneal limbus.

Next, a total volume of 2.0 μL of PBS (vehicle control) or 500 mM tranylcypromine (1000 nmol) mixed with 10 mM NMDA (20 nmol) was injected into the vitreous cavity.

references: wikipedia

Storage:

Storage condition: the storehouse is ventilated and dry at low temperature, and stored separately from oxidants and food additives

Long term storage: -20°C Freezer, Under inert atmosphere
 

Service:

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

Shipping:

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Learn more about us

Packaging and shipping

tranylcypromine hemisulfate
tranylcypromine hemisulfate
tranylcypromine hemisulfate
tranylcypromine hemisulfate