High quality S-Adenosyl-L-methionine powder supplier | cas 29908-03-0

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Products Description

Name: S-Adenosyl-L-methionine

Cas: 29908-03-0

Purity: 99%min


Basic Info:

CAS No.:






Stock Availability

In stock

Brand Name

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Product Introduction:

S-Adenosyl-L-methionine is a coenzyme involved in methyl transfer reaction with an activated methyl group, which is present in all eukaryotic cells. After losing this activated methyl group, it will become S-adenosyl-L-homocysteine (SAH).

S-Adenosyl-L-methionine was first discovered by scientists (Cantoni) in 1952. It is synthesized by adenosine triphosphate (ATP) and methionine in the cell through Methionine Adenosyl Transferase (Methionine Adenosyl Transferase). When it is used as a coenzyme to participate in the methyl transfer reaction, it loses a methyl group and becomes an S-adenosyl group. Homocysteine.

Most of S-Adenosyl-L-methionine is produced in the liver. In advanced organisms, more than 40 anabolic or catabolic chemical reactions involve the transfer of the methyl group of S-adenosylmethionine to substrates such as nucleic acids, proteins, and fats.

Properties of S-Adenosyl-L-methionine:

  • Melting point: 247-249ºC
  • Molecular formula: C15H22N6O5S
  • Molecular weight: 398.44
  • PSA: 547.02000
  • Storage conditions: -20°C


Product NameS-Adenosyl-L-methionine
CAS No.29908-03-0
Appearance White crystalline powder
Content99% min
Shelf Life2 years
Packing1kg/bag,25kg/bag or as your requirements

Pharmacological action:

S-Adenosyl-L-methionine is a physiologically active molecule that exists in all tissues and body fluids of the human body.

It acts as a methyl donor (transmethylation) and the precursor (transsulfation) of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione and coenzyme A, etc.) to participate in important in vivo Biochemical reaction.

In the liver, the fluidity of the liver cell membrane is regulated by methylation of plasma membrane phospholipids, and the synthesis of sulfide products in the detoxification process can be promoted through the transsulfide reaction. As long as the bioavailability of adenosylmethionine in the liver is within the normal range, these reactions can help prevent intrahepatic cholestasis.

Physiological effect:

S-Adenosyl-L-methionine and glutathione (GSH) are two important biologically active molecules in the organism.

S-Adenosyl-L-methionine, the active form of methionine, is widely present in plants and animals. It consists of the substrate L-methionine and adenosine triphosphate (ATP) through S-adenosylmethionine synthase ( EC2.5.1.6) Enzymatically synthesized.

SAM is closely related to many metabolic processes in the human body. It is a biochemical drug that improves cell metabolism. It can increase the levels of GSH, sulfate and taurine in the liver through transsulfide groups, and prevent hepatitis, fatty liver, liver fibrosis, and cirrhosis. And liver cancer, it can also prevent alcohol, drugs and cytokines from damaging the liver.

The effect of S-Adenosyl-L-methionine on the human body:

  • At present, there are two main types of S-Adenosyl-L-methionine(Adenosylmethionine 1,4-butanedisulfonate) on the market, one is adenosylmethionine succinate for injection, and the other is adenosylmethionine succinate enteric-coated tablets. Adenosylmethionine succinate is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor (transsulfuration) of physiological sulfide compounds (such as cysteine, taurine, glutathione and coenzyme A, etc.) Important biochemical reactions.
  • In the liver, oculomethionine regulates the fluidity of liver cell membranes by methylating plasma membrane phospholipids, and can promote the synthesis of sulfide products during the detoxification process through transsulfide reactions. These reactions help prevent intrahepatic cholestasis. Mainly used for intrahepatic cholestasis before cirrhosis and liver cirrhosis.
  • The multiple mechanisms of action of adenosylmethionine succinate are mainly reflected in the following aspects:
    1. Transmethylation: Improve the fluidity of liver cell membranes, enhance the activity of Na+-K+-ATPase, promote the secretion and operation of bile, and participate in the synthesis of neurotransmitters, which can improve the mood of patients.
    2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.
    3. Trans-acrylic gum base: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.

References: Wikipedia

Other reference information:

S-adenosyl-L-methionine (SAM) also has a good therapeutic effect on arthritis, fibrous muscle, migraine and other diseases, and has little side effects.

Clinically used to improve liver function. Combined with L-dopa for the treatment of Parkinson’s disease, it can improve the efficacy of L-dopa and reduce side effects. Local pain, temporary anxiety and insomnia can be seen at the injection site.


Pre-Sales Service

* Quick response and 24 hours online, professional team provides reasonable prices and high-quality products.

* All samples support testing.

* Each batch of products will be tested to ensure its quality.

* The packaging can also be a consumer’s request.

* Any questions will be answered within 24 hours.

* Provide trade invoice, packing list, packing list, COA, health certificate and certificate of origin. If your market has special needs, please let us know.


After-Sales Service

* Monitor real-time logistics information.

* Any questions about the product can be consulted at any time.

* The product can be returned if there is any problem.


  1. ≤50kg, express delivery is recommended, often called DDU service;
  2. ≤500kg, air freight is recommended, usually referred to as FOB, CFR or CIF service;
  3. > 500kg, sea freight is recommended, usually called FOB, CFR or CIF service;
  4. For more expensive products, please choose air and express delivery to ensure safety.


Do you accept sample order?

We will make samples before production, and after the samples are approved, we will start mass production. During the production process, we will conduct 100% inspection on the products, and then conduct random inspections on the products before packaging.


You can get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can also send us product details, and we will make products according to your requirements.

What’s your MOQ?

Our MOQ is 1kg. But we can usually accept quantities as low as 100g, provided that the sample fee is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

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