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retinoic acid
302-79-4

Name: Retinoic Acid

Cas: 302-79-4

Purity: 99%min

MOQ: 1KG

Directory Guidance on Retinoic Acid

Chemical Structure

retinoic acid

Basic Info:

CAS No:302-79-4
Formula:C20H28O2
EINECS:206-129-0
Stock AvailabilityIn stock
Brand NameLook chemical
OriginChina

Product Introduction:

Retinoic acid, the molecular formula is C20H28O2, is the metabolic intermediate item of vitamin A in the body, which generally impacts the development of bone and also promotes epithelial cell proliferation, distinction, keratolysis as well as various other metabolic effects.

Chordates call for retinoic acid, including all higher animals from fish to human beings.

It acts through the Hox gene, which ultimately controls the pre/post pattern in early developmental stages.

The critical role of retinoic acid in embryonic development mediates the high teratogenicity of retinoid drugs, such as isotretinoin, which is used to treat cancer and acne.

Oral high doses of preformed vitamin A (retinyl palmitate) and retinoic acid itself have the same teratogenic mechanism.

Retinoic acid is generally made use of in the therapy of acne vulgaris, psoriasis, ichthyosis, lichen planus, pityriasis rubra pilaris, keratosis pilaris, squamous cell carcinoma and cancer malignancy.

Nature and Specifications:

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Product Usage:

  • Retinoic Acid can be used for acne vulgaris, ichthyosis and psoriasis vulgaris.
  • It can also be used to treat multiple common warts and various skin diseases such as ichthyosis and keratosis pilaris.
  • Retinoic Acid can significantly inhibit the formation of experimental acne, and remove the keratin plug by regulating the abnormal process of keratinization of the pilosebaceous epithelium, thereby preventing and eliminating acne lesions.
  • Retinoic acid (ATRA) is a ligand of retinoic acid receptor (RAR) and RetinoidX receptor (RXR), which binds to RAR and also RXR as transduction factors to control the growth and distinction of regular cells as well as tumor cells.
  • Cytochrome P450s (CYPs) catalyze the hydroxylation of ATRA.
  • Retinoic acid guides the evolution of embryonicstemcells into neurons.

The Effect of Retinoic Acid:

Acne

  • Retinoic Acid has an anti-inflammatory result, and can likewise prevent the secretion of hair roots and skin glands, promote normalization of cell development, and boost the accumulation as well as clog of keratin inside as well as outside pores.

Delicate Skin

  • Retinoic Acid promotes keratinocyte production and makes the stratum corneum firm.
  • Promotes the formation of intercellular substance, making skin firm and smooth, making pores less visible.

Anti-photoaging

  • The main cause of photoaging is the increase of matrix metalloenzyme (MMP) of collagen decomposed in the dermis caused by ultraviolet rays. The main role of MPP is to metabolize collagen.
  • Retinoic Acid fights photoaging by preventing this behavior.
  • At the same time, Retinoic Acid also promotes collagen production, reducing skin problems such as fine lines and wrinkles.

Whitening

  • It can accelerate the metabolism of keratinocytes, and can also inhibit the production of melanocytes, which can improve pigmentation (equivalent to the effect of freckle).

Related References:

  1. Role of Retinoic Acid During Early Organogenesis” – PMC | Cell. 2008 Sep 19.
  2. Retinoic acid signaling mechanism and role” – PMC | Nature Reviews. Molecular Cell Biology. 2015 Feb.
  3. Wikipedia

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