Phosphocreatine CSA 67-07-2
Name:Phosphocreatine/Creatine phosphate
CAS: 67-07-2
Purity: 99%min
MOQ: 1KG
Chemical Structure
Basic Info:
| CAS No: | 67-07-2 |
| Name: | Phosphocreatine |
| EINECS: | 200-643-9 |
| Formula: | C4H10N3O5P |
| Weight: | 211.11 |
| Other Names: | Creatine phosphate |
| Type: | API |
| Shelf Life: | 3 years |
| Brand Name: | Look Chem |
| Place of Origin: | Shandong, China |
Product Introduction:
In the vast landscape of chemical and pharmaceutical raw materials, Phosphocreatine (PCr; also called creatine phosphate) is definitely a “hidden gem”.
To be exact, it is a vital “high-energy phosphate reserve” and “energy buffer” in cells. Its core function is very central: when the level of ATP (adenosine triphosphate) in our cells (especially cardiac and skeletal muscle cells) decreases due to ischemia, hypoxia or high-intensity exercise, it can quickly transfer its own phosphate group to ADP (adenosine diphosphate) like a “phosphate donor” under the catalysis of creatine kinase, rapidly regenerate ATP, so as to support the energy metabolism of cells.
As a raw material, it mainly exists in the form of Sodium Phosphocreatine for injection in the pharmaceutical field. It is an important pharmaceutical component for cardiovascular metabolic support therapy, and it is also a high-end raw material gaining significant attention in sports nutrition. For people in the industry, understanding Phosphocreatine is equivalent to understanding the key “buffer defense line” of cellular energy metabolism.
Nature and Specifications:
Specification
Product Nature
Specification
| Item | Specification |
| Product Name | Phosphocreatine |
| CAS No. | 67-07-2 |
| Appearance | Powder |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
Product Nature
| Appearance | White needle-like crystals or crystalline powder |
| Solubility | Soluble in water, insoluble in ethanol |
| Assay (Purity) | ≥ 98.0% (HPLC) |
| Storage Condition | 2-8°C, keep container tightly closed in a dry place |
Product Packaging
Phosphocreatine Uses:
As a substance with both medicinal value and biological activity, Phosphocreatine’s market position stems from its unique biochemical characteristics. Its application is not limited to the well-known “heart protection”, and the pharmacological mechanism behind it determines its application potential in many fields.
In cardiac surgery (such as cardiopulmonary bypass CPB), Phosphocreatine is often added as a component of cardioplegic solution.
Core logic: during cardioplegic arrest, the heart is in an ischemic state. Phosphocreatine helps maintain the high-energy phosphate level of cardiomyocytes and protect cell membrane function, aiming to alleviate ischemia-reperfusion injury, improve ischemia-related metabolic state and contribute to postoperative recovery.
In addition, for the adjuvant treatment of heart failure, myocarditis and acute myocardial infarction, it is often used as a drug to improve myocardial metabolism.
Although creatine monohydrate is more popular in the public fitness circle, at the physiological level, Phosphocreatine is the substance that directly participates in the ATP-PCr energy system.
During very short, high-intensity efforts (roughly the first 0–10 s), energy is primarily supplied by ATP and PCr via the ATP–PCr system.
The brain is a major energy consumer of the human body.
Phosphocreatine has relevant clinical application exploration in the field of Neurology, which is mainly used to assist in improving the energy metabolism of brain tissue.
At the same time, in some cases related to metabolic disorders, it is also used as one of the means to regulate cellular energy balance.
This is the key to distinguish Phosphocreatine from sugars for energy supply. The generation of ATP from ordinary energy sources (such as glucose) requires a series of complex steps such as glycolysis, tricarboxylic acid cycle, and often relies on oxygen. The phosphocreatine-creatine kinase system is anaerobic metabolism, and the reaction steps are simple and rapid. This rapid response mechanism has an irreplaceable buffering effect in dealing with cells’ urgent need for energy (such as acute ischemia or extreme exercise).
There is evidence suggesting that in addition to energy supply, it may help maintain the structural stability of cell membrane phospholipids through the interaction with cell membrane phospholipids. This characteristic has positive significance for reducing the leakage of intracellular enzymes and maintaining ion homeostasis (such as mitigating the risk of calcium overload).
Unlike many synthetic drugs, Phosphocreatine itself is a naturally occurring endogenous substance in the human body. This means that it has good biocompatibility. Its metabolites in the body are mainly creatine (partially converted to creatinine and excreted by the kidney) and inorganic phosphorus. At a reasonable dose, it is generally well tolerated, which is an additional item for the safety evaluation of clinical medication.
Industry Q & A
A: Not exactly the same thing.
Creatine monohydrate is the “precursor” and raw material of Phosphocreatine. After taking it, the body needs to consume ATP to phosphorylate it, convert it into Phosphocreatine and store it in muscle.
Phosphocreatine is an active form that has bound phosphate groups.
From the application level, Sodium Phosphocreatine is usually used as a pharmaceutical grade raw material, and the production threshold, impurity control requirements and price are much higher than creatine monohydrate, which is usually used as a food / sports nutrition additive.
A: The high-energy phosphate bond in Phosphocreatine molecule is unstable in acidic environment (such as gastric acid), which is easily hydrolyzed to creatine and inorganic phosphorus, thus reducing the bioavailability. Therefore, in order to ensure the therapeutic efficacy, the clinical mainstream uses intravenous infusion. At present, some enterprises are also exploring enteric coating technology or special encapsulation technology, trying to overcome the difficulties of oral absorption.
A: relatively strict. As a fine chemical operation, delivery and storage should be cautious. Sodium Phosphocreatine is hygroscopic and relatively sensitive to heat. Dampness or heat may lead to degradation, causing impurities exceeding limits, and directly affecting the compliance of drugs.
A: mainly energy metabolism support. Adding Phosphocreatine to cardioplegic solution is equivalent to providing an exogenous high-energy phosphate substrate for cardiomyocytes. When the heart cannot obtain oxygen and substrates through normal blood flow, it helps maintain the basic energy metabolism required for cell survival, aiming to reduce the damage caused by ischemia and create more favorable biochemical conditions for the smooth resumption of cardiac activity.
A: It is neither cost-effective nor necessary. Phosphocreatine preparations are mainly aimed at high-intensity recovery or medical level rehabilitation support of professional athletes. Ordinary people don’t need to “use a sledgehammer to crack a nut”.
A: The difficulty lies in purification, impurity removal and polymorph control. During the synthesis process, side reactions should be strictly controlled to remove inorganic salts and specific organic impurities. In addition, the crystallization process of Sodium Phosphocreatine is difficult to control, and the crystal form directly affects the solubility and stability of the product.
A:Although it is an endogenous substance and has been used in the treatment of some pediatric heart diseases, as a drug, the medication for special populations has strict dose and indication requirements. As a raw material supplier, we emphasize that the end products must comply with the drug administration regulations, be used strictly under the guidance of doctors, and never be recommended to pregnant women or children as ordinary supplements.
Related References:
Phosphocreatine Manufacturer & Supplier
As an experienced Phosphocreatine manufacturer and supplier, Look Chemical is committed to producing and selling high quality products.
We cooperate and trade with 6000+ factories around the world, and our high-quality products and excellent services make us enjoy a high reputation internationally.
As Phosphocreatine supplier, Look Chemical provides supply chain solutions to partners and customers in a wide range of industries. We offer competitive pricing and quality products.
If you have a demand for this product, please contact our company’s sales staff, we will provide you with a solution in the shortest time.
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I’m william, CEO of Look Chemical Co., Ltd. Welcome to visit our company. As China’s top Global Supply Specialist of chemicals, we have always been adhering to the principle of “service first, quality first, mutual benefit”, and we insist on Create value for customers and grow together with customers.
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