Supply high purity phloretin powder 99% cas 60-82-2

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phloretin
60-82-2

Products Description

Name: Phloretin powder

Cas: 60-82-2

Purity: 99%min

MOQ: 1KG

Basic Info:

CAS No.:

60-82-2

Formula:

C15H14O5

EINECS:

200-488-7

Stock Availability

In stock

Brand Name

Look chem

Origin

China

Product Introduction:

Phloretin, alias trihydroxyphenol acetone 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone. It is a new type of natural skin whitening agent recently researched , mainly distributed in the peel and root bark of juicy fruits such as apples and pears.

It can be used in facial masks, skin creams, lotions and essences. It is a pearl white crystalline powder, soluble in ethanol and acetone, but almost insoluble in water.

For human skin, it has strong antioxidant and photoprotective effects (it can eliminate the increase of free radicals in the skin caused by ultraviolet rays and damage to cells and DNA), and it can also inhibit matrix metalloproteinases (MMP-1). ) And the activity of elastase, these enzymes can degrade the connective tissue of the skin and play an important role in the skin photoaging process.

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The properties of phloretin:

  • Melting point: ~260°C
  • Boiling point: 337.26°C(roughestimate)
  • Density: 1.1827(roughestimate)
  • Refractive index: 1.573-1.575
  • Storage conditions: 2-8°C
  • Acidity coefficient (pKa): 7.16±0.40(Predicted)
  • Form: Powder

Specification:

ItemSpecification
Product NamePhloretin
CAS No.60-82-2
Appearance White crystalline powder
Content99% min
Shelf Life2 years
Packing1kg/bag,25kg/bag or as your requirements

Biological activity of phloretin:

  1. Antioxidant and antioxidant effect
    • The peroxidative activity of flavonoids was identified in the 1960s, and many flavonoid polyhydroxyl structures are believed to have antioxidant properties because they can chelate with metal ions and have significant antioxidant properties.
    • It has strong antioxidant properties, and the antioxidant concentration of oil is between 10-30PPm, which can remove free radicals from the skin. Disease, external use can prevent sugar components from entering the epidermal cells, suppressing the excessive secretion of skin glands and treating secretory acne.
    • Studies have shown that phloretin inhibits the activity of melanocytes and has a whitening effect on various skin spots. It has a good inhibitory effect on tyrosinase and is a very safe and effective freckle whitening agent. Phloretin has a very good moisturizing effect and can be absorbed 4 to 5 times its own weight. As a very safe and effective transdermal penetration enhancer, phloretin may be more effective by promoting the absorption and utilization of other functional factors in the formulation. Because phloretin has a good LOX inhibitory effect, phloretin is a good anti-hair loss agent.
  2. Anti-inflammatory and immunosuppressive effect
    • Studies have shown that the development of inflammation is associated with NO. NO is catalyzed and synthesized by NO synthetase, and excess NO is catalyzed by inducible NO synthetase under pathological conditions. Under the action of phloretin, the release of NO from macrophages was greatly reduced under the stimulation of lipopolysaccharide and IFN-γ inhibition, and the phagocytosis rate of megalithic cells was also significantly reduced under the action of phloretin. Therefore, phloretin has potential anti-inflammatory effects.
    • In terms of immunosuppression, phloretin is known as a competitive inhibitor of the sodium D-glucose cotransporter. Because it can increase the fluidity of the intracellular lipid bilayer, it can increase the type and activity of drugs delivered through the skin.
  3. Anti-cancer and anti-cancer effect
    • γδ T cells are innate immune T cells that are widely present in mucosal and epithelial tissues of the digestive and respiratory systems. In addition to some functional properties similar to αβT cells, the antitumor effect also recognizes antigens without MHC. , It directly recognizes non-peptide antigens, protein and peptide antigens, has an antigen extraction function, and can play a role in immune regulation through cell contact and cytokine secretion.
  4. It also has anti-diabetic and anti-Parkinson’s disease effects.
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Related research:

  • With the increase in the market share of plant functional cosmetics, phloretin has successfully attracted the attention of researchers in the beauty industry with its multi-functional beauty effects. Studies have found that phloretin has various pharmacological effects such as anti-oxidation, anti-tumor, anti-inflammatory, immunosuppressive, and promoting bone formation. In addition, it also has the effects of whitening and removing acne.
  • It can be directly absorbed by the human body, but in plants, there is very little naturally occurring phloretin, and most of the phloretin exists in the form of its glycoside derivative-phloridin. Phloridin absorbed by the human body is in the gastric mucosa. After the glycosidic group is removed to produce phloretin, it can enter the circulatory system and exert its effect.

References: Wikipedia

Service:

Pre-Sales Service

* Quick response and 24 hours online, professional team will provide you with the best prices and high-quality products.

* The sample supports testing.

* Each batch of products will be tested to ensure its quality.

* Packaging can also be done according to customer requirements.

* Any inquiry will be answered within 24 hours.

* We provide commercial invoice, packing list, packing list, COA, health certificate and certificate of origin. If your market has any special requirements, please let us know.

 

After-Sales Service

* Real-time control of logistics information.

* You can consult at any time if you have any questions about the product.

* The product can be returned if there is any problem.

Shipping:

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

FAQ

Do you accept sample order?

We will make samples before mass production, and after the samples are approved, we will start mass production. 100% inspection is carried out during the production process, and then random inspection is carried out before packaging.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us your product specifications and requirements, and we will manufacture products according to your requirements.

What’s your MOQ?

Our MOQ is 1kg. But we can usually accept a lower quantity, such as 100g, provided that the sample fee is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

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Shandong Look Chemical

Contact us for the latest quotation and free samples of Phloretin powder

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