n-Butyllithium is a chemical compound with the formula C4H9Li. This colorless, water-soluble liquid is used as a strong base in organic synthesis. The chemical was discovered in 1883 by German chemist Karl Butyler and was the first organolithium compound to be synthesized.
It has a density of 0.78 g/mL in water, and it melts at -62°C. It is soluble in benzene, ethers, chloroform, and acetone, insoluble in hexane and petroleum ether.
N-Butyllithium is used in organic synthesis as an organolithium reagent and as a catalyst for polymerization reactions. It is also used as a reducing agent in analytical chemistry and electrochemistry, such as in the determination of the amount of water present in alcohols after hydrolysis of esters.
In chemical laboratories, organometallic reagents are common reagents, and organolithium reagents, which are widely used in organic synthesis, are one of the representatives. Organolithium reagents are often corrosive and flammable, and are prone to violent reactions and even rapid combustion and explosion in contact with water and oxygen. Most of the laboratories using them have formulated extremely strict safety operation rules.
Application of n-butyllithium in the pharmaceutical industry
n-butyllithium used as initiator and other reagents
Catalysts for organic reactions are widely used in organic catalytic reactions in pharmaceutical intermediates, liquid crystal monomers, pesticides and rubber industries.
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
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