C6H12ClNO2
Bulk Methyl L-Prolinate Hydrochloride CAS 2133-40-6 Factory Direct |Sourcing Guide
Bulk Methyl L-Prolinate Hydrochloride CAS 2133-40-6 Factory Direct
The global pharmaceutical, biochemical synthesis, and custom peptide engineering sectors are navigating a strict shift toward high-yielding, clean-profile building blocks. As clinical pipelines expand, sourcing agents require amino acid derivatives that prevent racemization and eliminate trace impurities. Methyl L-prolinate hydrochloride (CAS 2133-40-6) stands out as an essential chiral intermediate for synthesizing complex peptidomimetics, proline-based catalysts, and active pharmaceutical ingredients (APIs).
As a primary chemical synthesis factory with dedicated organic esterification corridors, we deliver premium-grade L-proline methyl ester HCl directly to global B2B procurement networks, ensuring stable supply chains and competitive factory-direct pricing.
Name: Methyl L-Prolinate Hydrochloride
CAS: 2133-40-6
Purity: 98.5% min
MOQ: 25 KG
Sourcing Guide of Methyl L-Prolinate Hydrochloride CAS 2133-40-6
Chemical Structure
Basic Chemical Info
CAS 2133-40-6 (chemically known as L-proline methyl ester hydrochloride) is the stable hydrochloride salt form of the methyl ester derivative of L-proline. By converting the carboxylic acid group into a methyl ester and stabilizing the secondary amine as an HCl salt, this molecule provides excellent protection during solid-phase and liquid-phase peptide coupling reactions, preventing unwanted polymerization.
Core Technical Profile
| Analytical Parameter | Certified Factory Standard |
|---|---|
| CAS Registry Index | 2133-40-6 |
| Molecular Configuration | C6H12ClNO2 |
| Purity Assay (HPLC/Titration) | ≥98.5% or ≥99.0% (Custom high-purity tiers available) |
| Specific Optical Rotation | −33.0∘to−36.0∘ (𝑐=1,MeOH) |
| Physical Appearance | White to off-white crystalline powder |
| Melting Point Range | 65.0∘C – 71.0∘C |
| Moisture Content (KF) | ≤0.5% |
Application
FAQ
Q1: Can Methyl L-prolinate hydrochloride be utilized directly in peptide synthesizers?
Yes. It acts as an excellent C-terminal protected building block. The amine site is readily available for coupling reactions once neutralized with an appropriate tertiary amine base within your automated or manual synthesis setup.
Q2: What are the optimal warehouse conditions to maximize shelf life?
The product should be stored in a cool, dark, dry warehouse in its original, unopened packaging, preferably between 2°C and 8°C for long-term inventory stability. Keeping the container tightly sealed protects the hygroscopic crystalline structure.
Q3: What is your minimum industrial ordering quantity (MOQ)?
For standard stock specifications, our commercial MOQ begins at 25kg (1 drum). Smaller trial batches (e.g., 1kg–5kg) for laboratory scale-up or formula validation can be arranged through our sales desk.
Advanced Production Technology
Our chemical plant synthesizes Methyl L-prolinate hydrochloride utilizing a clean, highly optimized thionyl chloride or gas-phase HCl esterification route directly from natural L-proline:
[Natural L-Proline Feedstock]
│
▼ (Anhydrous Reaction with Thionyl Chloride & Methanol)
[Esterification under Cryogenic Temperature Control]
│
▼ (Multi-Stage Controlled Crystallization)
[Centrifugal Solvent Removal & Vacuum Drying]
│
▼ (High-Purity Crystals CAS 2133-40-6)
- Cryogenic Reaction Control: By maintaining strict low-temperature parameters during the initial activation stage, we completely suppress heat-induced racemization. This guarantees that the specific optical rotation remains exceptionally high and uniform across every batch.
- Solvent-Free Vacuum Curing: The final crystalline slurry undergoes multi-stage washing followed by fluid-bed vacuum drying. This step removes trace volatile organics and free hydrochloric acid, resulting in a low-odor, free-flowing crystalline matrix.
Product Advantages: Compared with Competitors
When managing bulk intermediate procurement, minor composition shifts alter your final chemical yields. Here is how our factory-refined material outperforms standard trade options:
- Strict Enantiomeric Purity: Standard trading lots often suffer from minor D-isomer contamination due to loose thermal management during scale-up. Our specialized process keeps the D-proline ester footprint below detectable limits, protecting your downstream asymmetric syntheses.
- Low Free Hydrochloric Acid Traps: Excessive free HCl causes moisture absorption and degrades core reactive compounds. Our unique crystallization process binds the HCl molecule strictly within the crystal lattice, eliminating excess acid gas.
- Excellent Solubility Behavior: With a highly managed moisture index, our crystalline powder dissolves instantly in dichloromethane (DCM), chloroform, and water without leaving un-dissolved micro-particles.
Plant Infrastructure & Scalable Production Capacities
Partnering directly with our heavy-industrial manufacturing plant ensures long-term supply security and extensive corporate backing:
- Scalable Annual Output: Our dedicated amino acid derivative workshops maintain an annual capacity exceeding 80 metric tons, backed by reliable raw material supply agreements.
- Rigorous Quality Management: Our manufacturing facility is audited and operates under ISO 9001:2015 and ISO 14001 parameters.
- Complete Regulatory Dossier Support: To facilitate smooth customs clearance, every outbound shipment is backed by a full documentation package, including matching batch Certificates of Analysis (COA), comprehensive MSDS/SDS, Technical Data Sheets (TDS), and HPLC/NMR purity charts.
Industrial Packaging, Sealing & Global Freight Logistics
Because Methyl L-prolinate hydrochloride is highly hygroscopic, proper sealing and climate management during transport are essential to maintain product integrity:
- Commercial Packaging Options: We ship in heavy-duty 25kg fiber drums lined with dual-layer anti-static polyethylene bags, as well as customizable 1kg aluminum foil bags for pilot manufacturing runs.
- Headspace Humidity Barriers: Every container undergoes an ultra-dry nitrogen purge and heat-sealing before palletization. This completely eliminates moisture absorption and clumping risks during long-distance ocean transit.
- Strategic Marine Port Access: Located near major global shipping ports, we provide flexible shipping terms under FOB, CFR, CIF, and DDP terms, handled by certified freight forwarders.
Quality Control and Warehousing Infrastructure
Finished Product Quality Control
✅ Comprehensive quality control for every shipment prior to dispatch
✅Complete batch traceability system
Testing equipment
✅ In-house quality control laboratory
✅ Qualified personnel and a full range of testing equipment
Warehouse Facilities
✅ Finished goods warehouse: 300 m²
✅ Storage tank capacity: 50 tonnes
✅ Storage temperature range: 15–25°C
✅ Explosion-proof and anti-static design
Quality control documents provided with each batch партией
✅ COA (Certificate of Analysis)
✅ SDS (Safety Data Sheet)
✅ Certificate of Origin
✅ Packing List / Commercial Invoice
Company Photo Gallery
🔬 Laboratory
🏭 Our Factory
⚙️ Production Workshop
🛠 Production Equipment
👨🔬 Company employees
📜Patents and Certificates
🔬 Laboratory
Research and Analytical Laboratory SD LOOK CHEM
SDLOOK CHEM’s research and analytical center occupies over 1,500 square meters. It includes modern specialized laboratories: an analytical testing center, an organic synthesis laboratory, a formulation development laboratory, a physicochemical laboratory, an HPLC laboratory, a gas chromatography (GC) laboratory, and a pilot laboratory for pilot industrial testing.
The R&D team consists of 10 people.
Highly qualified specialists, including 3 Doctors of Science and 7 holders of a master’s degree.
Core activities include research and analysis of organic intermediates, pharmaceutical raw materials, food additives, and industrial chemicals.
The laboratory is equipped with state-of-the-art analytical instrumentation—including HPLC, GC, FTIR, NMR, and AAS—enabling a full operational cycle ranging from fundamental research to pilot-scale production. The company offers services in custom product development, formulation, and professional laboratory analysis.
All products undergo rigorous laboratory testing prior to shipment, ensuring consistent and reliable quality for every batch.
Laboratory positioning
The Zhishang Chemical research laboratory serves as the company’s key hub for technological innovation. The laboratory specializes in research, analysis, and applied development regarding organic intermediates, pharmaceutical raw materials, food additives, and industrial chemicals, providing robust scientific and technical support for product quality and the company’s continuous development.
Intellectual property results
📜 6 registered invention patents
📜 3 invention patents pending
📜 12 utility model patents
Quality Control (QC) Laboratory
✅ Area: approximately 150 m²
✅ Independent laboratory, fully isolated from production areas
✅Constant temperature and humidity control systemstart=”2157″ data-end=”2160″ />✅ Equipped with professional analytical and testing equipment
✅Staff of 5 quality control specialists
🏭 Our Factory
Production facility area: approximately 10,000 m²
⚙️ Production Workshop
Production Workshop
✅ Workshop area: approximately 3 000 м²
✅ Closed production environment prevents contamination.
✅ Equipped with a ventilation and exhaust system.
✅ Explosion-proof and anti-static design
✅ Emergency showers and eyewash stations
✅ 24-hour video surveillance (24/7)
🛠 Production Equipment
👨🔬 Company employees
Laboratory Personnel
Administrative and commercial department
✅ A sales team of over 10 specialists
✅ Customer service in Chinese, English, and Russian
✅ 24/7 customer support
✅ Modern video conferencing tools for conducting remote negotiations and online enterprise audits (virtual inspection visits)
CEO
📜Patents and Certificates
Intellectual property results
📜 10 registered patents for inventions have been obtained.
📜 3 invention patents are under review (applications have been filed).
📜 12 utility model patents obtained
Technical Support & Analytical Warranties
Our commitment to your business extends far beyond product delivery. We provide dedicated support to safeguard your operations:
- Peptide De-protection & Coupling Guidance: Our in-house R&D chemists can provide technical parameters regarding organic base selection (such as DIEA or Triethylamine) to release the free amine without initiating ester hydrolysis.
- Regulatory Audit Cooperation: We offer full transparency and documentation support to streamline your brand’s third-party pharmaceutical quality assurance audits.
- Two-Year Retention Library: Physical reference samples from every shipped batch are retained in our quality control lab for 24 months, enabling fast verification and analysis if any processing discrepancies arise on your line.
Contact Us / Request a Quote
To optimize your production lines and secure competitive direct-from-factory pricing on bulk volumes of Methyl L-prolinate hydrochloride (CAS 2133-40-6), contact our international export office today for an official price quote.
