Lithium Diisopropylamide CAS 4111-54-0
Ceteareth 25 CAS 68439-49-6
11/08/2022
Cumene Hydroperoxide CAS 80-15-9
05/08/2022
Name: Lithium Diisopropylamide
Cas: 4111-54-0
Purity: 99%min
MOQ: 1KG
Directory Guidance on Lithium Diisopropylamide
Chemical Structure
Basic Info:
| CAS No: | 4111-54-0 |
| Formula: | C6H16LiN |
| EINECS: | 223-893-0 |
| Stock Availability | In stock |
| Brand Name | Look chemical |
| Origin | China |
Product Introduction:
Lithium diisopropylamide, also known as LDA, has a molecular formula of C6H16LiN. In organic chemistry, LDA is often used as a base to deprotonate hydrocarbons.
Its color is similar to that of n-butyllithium solution, very pale yellow and transparent. Because butyllithium is easily oxidatively decomposed into lithium oxides or something, precipitation and discoloration occur.
The reagent is soluble in Et2O, THF, DME, HMPA, and becomes unstable when the temperature rises above 0oC. But its hexane or pentane solution is stable for several weeks at room temperature, and its complex with THF is quite stable in cyclohexane and heptane.
Lithium diisopropylamide is widely used because it is soluble in non-polar organic solvents.
It is often used as a base in synthetic chemistry to deprotonate hydrocarbons and sometimes to generate carbanions and enolates.
It can be prepared by the reaction between metal lithium and diisopropylamine, or by the reaction between diisopropylamine and butyllithium or methyllithium.
Nature and Specifications:
Product Nature
Specification
Product Nature
- Density: 0.864 g/mL at 25 °C(lit.)
- Boiling point: 65 °C
- Melting point: 38-42ºC
- Flash point: 91 °F
- Water solubility: decomposes
- Vapor Density: >1 (vs air)
Specification
| Item | Specification |
| Product Name | Lithium Diisopropylamide Powder |
| CAS No. | 4111-54-0 |
| Appearance | White crystalline powder |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
Product Packaging
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Product Usage:
Lithium diisopropylamide (LDA) is a sterically hindered non-nucleophilic strong base reagent widely used in organic synthesis, with pKa = 35.7 in tetrahydrofuran. Often used to generate carbanions and enolate ions.
It is often used as a base in synthetic chemistry to deprotonate hydrocarbons and sometimes to generate carbanions and enolates.
Lithium diisopropylamide is widely used because it is soluble in non-polar organic solvents. Lithium diisopropylamide is widely used in the enolation reaction of aldehydes, ketones and esters, and the generated enolate ions are captured by silicon derivatives or sulfonyl groups to generate corresponding silyl ethers or sulfonates.
Can be used as single electron donor or hydride ion donor.
LDA is widely used in the enolization of aldehydes, ketones and esters, and the generated enolate ions are captured by silicon derivatives or sulfonyl groups to generate corresponding silyl ethers or sulfonates.
Catalyzes the α-position alkylation of aldehydes, ketones, esters and amides. Due to the activation of the α-methylene and methine groups by the carbonyl groups in these compounds, LDA can take up their protons to generate carbanions at low temperatures.
Related References:
- “Experimental Reaction of Lithium Diisopropylamide with α-Fluoroacetate” – Springer, Link | September 1996.
- “Lithium diisopropylamide-mediated ortholithiation of 2-fluoropyridines: rate, mechanism, and autocatalysis” – NIH, PubMed | 2013 May 3.
- Wikipedia
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