Levomefolate calcium (INN). Also known as L-5-MTHF, L-5-Methyltetrahydrofolate Calcium, is the calcium salt of L-5-methyltetrahydrofolate, belonging to the folic acid group of vitamins (vitamin B9, folic acid), which is a coenzyme form of folic acid.
L-5-Methyltetrahydrofolate (L-5MTHF) is a vitamin B12 derivative found in our body. It acts as a cofactor in the conversion of homocysteine to methionine.
Calcium l-5-methyltetrahydrofolate (5-mthf) is a naturally occurring salt-forming methyl derivative of folic acid. Levomefolate calcium is the most biologically active and functional form of folic acid, which is easier to absorb than ordinary folic acid.
The unmethylated form of folic acid (vitamin B9) is the synthetic form of folic acid, which is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folic acid. It is a methylated derivative of tetrahydrofolate.
Levomefolate calcium is produced by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used for the production of 5,10-methylenetetrahydrofolate (MTHF) by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) also known as methionine synthase ( MS) cycles homocysteine back to methionine.
|Levomefolate Calcium Powder
|White or light grey solid
|1kg/bag,25kg/bag or as your requirements
Levomefolate calcium is the main biologically active form of folic acid used at the cellular level for DNA reproduction, cysteine cycle and regulation of homocysteine. It is also the form found in the circulation and crosses membranes into tissues and across the blood-brain barrier.
A lack of folic acid reduces the ability of cells to synthesize and repair DNA, and supplementing with folic acid may be a more beneficial approach. Increasing folic acid lowers homocysteine levels. And supports normal cell proliferation, vascular endothelial function, cardiovascular disease, nervous system function, and especially 5-MTHF supplementation during pregnancy has been shown to reduce the risk of neural tube defects and recurrence.
In cells, Levomefolate calcium is used for the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is a direct acceptor of one carbon unit for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine.
The chemistry of Levomefolate calcium is very interesting. It has many applications in the field of chemistry. For example, it can be used to make medicines and fertilizers, pesticides and explosives.
It is also used to make chemicals to kill parasites and bacteria, such as those found in tuberculosis. L-folate can be converted to L-5′-methylthiocycline by folate and methyltetrahydrofolate synthase, a highly conserved family of enzymes.
L-5-Methyltetrahydrofolate Calcium has been proposed for the treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancer. It bypasses several metabolic steps in the body and better binds thymidylate synthase to metabolites (fDumps) of certain drugs.
Levomefolate calcium is water-soluble and excreted mainly by the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached within 1 to 3 hours after oral or parenteral administration. Peak concentrations were found to be more than 7-fold higher than folic acid (129 ng/ml vs. 14.1 ng/ml).
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