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Gossypol-Acetic Acid CAS 12542-36-8
Gossypol-Acetic Acid is a natural polyphenolic compound derived from the seeds of the cotton plant (Gossypium), structurally stabilized by a 1:1 molar ratio complexation with acetic acid. This unique formulation drastically overcomes the inherent oxidative instability of free gossypol. Globally recognized for its diverse pharmacological activities, it serves as a critical active pharmaceutical ingredient (API) and reference standard in reproductive medicine, antiviral research, and anti-tumor therapeutic screening.
Name: Gossypol-Acetic Acid
CAS: 12542-36-8
Purity: 99%min
MOQ: 1KG
Directory Guidance on Gossypol-Acetic Acid
Chemical Structure
Product Profile and Core Specifications:
Gossypol-Acetic Acid is a natural polyphenolic compound derived from the seeds of the cotton plant (Gossypium), structurally stabilized by a 1:1 molar ratio complexation with acetic acid. This unique formulation drastically overcomes the inherent oxidative instability of free gossypol. Globally recognized for its diverse pharmacological activities, it serves as a critical active pharmaceutical ingredient (API) and reference standard in reproductive medicine, antiviral research, and anti-tumor therapeutic screening.
Definitive Technical Parameters:
- International Nomenclature: Gossypol-Acetic Acid / Gossypol Acetate / 2,2′-Bis(formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) acetic acid complex
- CAS Registry Number: 12542-36-8
- Molecular Formula: C30H30O8 · C2H4O2
- Molecular Weight: 578.61 g/mol
- Appearance: Fine yellow to bright yellow crystalline powder
- Assay (HPLC): ≥ 98.0% / ≥ 99.0% (Premium Pharmaceutical Grade)
- Specific Rotation: [α]D20 = -325° to -340° (for specialized enantiomeric purity profiles)
- Heavy Metals (Pb, As, Cd, Hg): ≤ 10 ppm (Total)
Advanced Extraction & Crystallization Technology:
The primary challenge of raw cotton extraction is eliminating toxic co-extracts and ensuring low bound-gossypol ratios. Our manufacturing facility utilizes a proprietary multi-stage, closed-loop extraction framework:
Low-Temperature Solvent Maceration: Raw cotton seeds undergo extraction in a cryogenic, oxygen-free fluidic system. This precise thermal management suppresses the thermal degradation of the sensitive polyphenolic rings, retaining maximum bioactivity
Chromatographic Polar Phase Separation: The crude extract is run through advanced preparative chromatography systems to selectively partition pure gossypol from natural pigments, phospholipids, and fatty acids, ensuring an exceptional chemical purity profile.
Controlled Stoichiometric Complexation: Pure gossypol is reacted with ultra-pure glacial acetic acid in a phase-controlled crystallization chamber. By maintaining a strict 1:1 molecular balance, we produce uniform, needle-like crystals that feature superior shelf-life and zero background amorphous structures.
Production Capacity and Robust Inventory Program:
We specialized in transforming delicate plant-derived chemistry into dependable, large-scale commercial volumes for global contract manufacturing organizations (CMOs):
- Annual Output Scalability: Our dedicated natural extraction lines generate up to 8 hundred kilograms / metric tons of high-purity Gossypol-Acetic Acid annually.
- Strategic Buffer Stocks: To protect international buyers against volatile cross-border shipping and customs timelines, we maintain a permanent, climate-regulated buffer inventory of not less than 30 kilograms at our central logistics hub. Orders are ready for compliance validation and customs dispatch within 48–72 hours.
- Enantiomeric Consistency: Utilizing massive micro-powder blenders, we homogenize large production runs, meaning your R&D teams do not need to recalibrate automated high-performance liquid chromatography (HPLC) or spectrophotometric assay equipment for every new shipment.
Product Packaging
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Competitive Factory Advantages:
- Direct-from-Source Economics: By bypassing multi-tiered international brokers and trading houses, we provide transparent, direct factory-gate pricing (FOB, CIF, CFR, DAP) that significantly reduces your raw material acquisition costs.
- Independent Quality Control (QC) Auditing: Every production batch is subjected to comprehensive HPLC profiling, Proton NMR verification, and heavy metal atomic absorption testing. A comprehensive Batch Certificate of Analysis (COA) is enclosed with every single package.
- Custom Customization Options: For large-scale manufacturing applications, we can modify the mesh size (particle size distribution) or supply the product pre-dissolved or pre-formulated in specific dry solvent matrices according to your proprietary Standard Operating Procedures (SOPs).
Related Industry Q&A
Q1: What is the standard situation of Gossypol-Acetic Acid?
A: Gossypol-Acetic Acid is a natural substance derived from all-natural gossypol, coming from the polyphenolic naphthalene framework. Its look is generally light yellow to yellow powder, with particular chemical task and intricate architectural features.
Q2: What signs should be concentrated on when purchasing Gossypol-Acetic Acid?
A: When acquiring, vital signs such as purity (such as HPLC web content), pollutants, moisture web content, recurring solvents, and isomer proportion must be given unique focus. These variables will straight impact its subsequent usage and research study stability.
Q3: Exist various specs or qualities of Gossypol-Acetic Acid?
A: Yes, there are typically various specifications such as research study quality and commercial quality in the market. Different qualities have differences in purity, contamination control, and screening standards. When purchasing, the ideal quality must be picked according to the real use.
Q4: What should be kept in mind during the storage and transport of this item?
A: Gossypol-Acetic Acid must be secured and kept in an amazing, completely dry, and dark environment, preventing heats and humid conditions; Throughout transportation, it is essential to avoid moisture and solid light direct exposure to make certain the stability of the item is not impacted.
Q5: What facets should be reviewed when selecting distributors?
A: It is suggested to concentrate on analyzing the vendor’s manufacturing qualifications, quality assurance system (such as whether they have full screening records), batch security, and supply capacity, while likewise recognizing their historic teamwork cases and market reputation.
Q6: What are the general product packaging types of Gossypol-Acetic Acid?
A: Typical packaging consists of aluminum foil bags, sealed plastic bottles, or cardboard drums lined with moisture-proof bags, and so on. Various product packaging requirements can be chosen according to the purchase quantity and transportation requirements.
Q7: What elements impact the price of this basic material?
A: The rate is primarily affected by purity needs, purchase amount, manufacturing process complexity, and market supply and need, and there might likewise be particular differences between various providers.
Q8: Can you give relevant screening reports?
A: Regular suppliers can typically offer COA (Certificate of Analysis), MSDS (Security Data Sheet) and other files to verify item high quality and security details. It is suggested to demand and validate them prior to procurement.
Q9: Exactly how to ensure security in between sets?
A: Stability primarily depends upon production procedure control and quality evaluation system. It is suggested to pick distributors with fully grown production experience and perform little set screening and verification during the very first cooperation.
Q10: Is it required to perform example testing before procurement?
A: It is suggested to carry out sample testing first to validate whether its purity, solubility, and actual efficiency fulfill the use demands, consequently lowering the threat of large procurement.
Related References:
Chemicalbook
Packaging Integrity and International Logistics
Since Gossypol-Acetic Acid is highly sensitive to photolytic degradation, moisture, and ambient oxidation, we implement an uncompromised international export packaging standard:
- Standard Industrial Packaging:
- Laboratory / Pilot Scale: 10g, 50g, 100g, 1kg vacuum-sealed, light-blocking amber aluminum foil bags or amber glass jars blanketed under nitrogen.
- Commercial Scale: 5kg, 10kg, 25kg UN-approved fiber drums fitted with double anti-static, oxygen-barrier polyethylene inner liners.
- Thermal and Light Protection: All export containers are flushed with dry nitrogen, sealed with desiccant packs, and packed into outer protective crating to completely shield the material from ambient heat and UV radiation during ocean or air transit.
- Global Compliance Shipping: We handle complete hazardous or non-hazardous chemical customs documentation (depending on final country regulations), providing a fully compliant, multi-lingual Material Safety Data Sheet (MSDS/SDS) in strict alignment with GHS and international regulations.
Company Info
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