Esmolol CAS 81147-92-4

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Esmolol
81147-92-4

Name: Esmolol Powder

Cas: 81147-92-4

Purity: 99%min

MOQ: 1KG

Basic Info:

CAS No:81147-92-4
Formula:C16H25NO4
EINECS:N/A
Stock AvailabilityIn stock
Brand NameLook chemical
OriginChina

Product Introduction:

Esmolol, also known as Ailuo, Emolol, Brevibloc, chemical name is 4{[3-[(1-methylethyl)amino]-2hydroxy]propoxy}phenylpropionic acid methyl ester It is a kind of receptor blocker with strong selectivity, fast onset and very short duration of action on the heart.

Its pharmacological effects are: inhibiting the self-discipline of the sinoatrial node, prolonging the conduction of the atrioventricular node, reducing the heart rate, reducing the myocardial contractility, reducing the oxygen consumption, reducing the cardiac load, and having a weak effect on the peripheral vascular resistance.

Esmolol mainly acts on the β1 receptor of the myocardium, and also has a blocking effect on the β2 receptor of the trachea and vascular smooth muscle in large doses. No intrinsic sympathomimetic or membrane stabilizing effects at therapeutic doses. Antiarrhythmic acts mainly by inhibiting the stimulation of adrenaline on the cardiac pacemaker and slowing down the conduction of the atrioventricular node, and its main action site is the sinoatrial node and the atrioventricular node conduction system.

The antihypertensive mechanism of esmolol is not completely clear, and it is similar to propranolol, but when it produces the same β-receptor blocking effect, other selective and non-selective β-blockers such as bimetoprolol and propranolol Receptor blockers are more effective at lowering blood pressure.

Nature and Specifications:

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Product Usage:

Esmolol is a beta-blocker used to treat high blood pressure. It is also used to treat heart failure and atrial fibrillation. It is also used to treat heart failure, as well as to treat asthma and migraines. Its main uses are as follows:

  1. For the treatment of rapid supraventricular tachycardia, the effective rate is 66% to 79%. It can also be used to treat atrial fibrillation and atrial flutter, with an effective rate of 76% and 60%, respectively.
  2. Esmolol is a sympathetic drug that helps the body relax. It is used to treat coronary heart disease, angina and heart attack.
  3. It can also be used for myocardial infarction or after myocardial infarction, as well as for supraventricular tachyarrhythmia complicated by acute unstable angina pectoris. It can also be used for rapid antihypertensive treatment of hypertension during perioperative period and anesthesia.
  4. Clinically, esmolol is mainly used for supraventricular tachycardia during anesthesia.

Esmolol is an ultra-short-acting cardioselective β1-receptor blocker with no intrinsic sympathomimetic activity and membrane stabilization at therapeutic doses. It is characterized by fast onset of action and short duration of action.

The Effect of Esmolol:

Most adverse reactions were mild and transient. The most important adverse reaction is hypotension. Deaths have been reported with esmolol alone for ventricular rate control.

  1. Cardiovascular system: hypotension (asymptomatic hypotension, symptomatic hypotension), occasionally bradycardia, chest pain, heart block.
  2. Mental and nervous system: dizziness, headache, drowsiness, inattention, irritability, etc., occasionally fatigue, paresthesia, anxiety or depression, fantasy, etc. can be seen.
  3. Respiratory system: bronchospasm, dyspnea, nasal congestion.
  4. Gastrointestinal tract: Nausea, vomiting, occasional dry mouth, constipation, abdominal discomfort or taste inversion can be seen.
  5. Skin: flushing, edema, erythema, induration at the injection site, and occasionally thrombophlebitis.
  6. Others: Occasionally urinary retention, speech disorders, abnormal vision, shoulder and back pain, chills, fever, etc.

Difference Between Esmolol and Labetalol and Metoprolol:

Esmolol and labetalol are two widely used beta-blockers. They are used to treat high blood pressure, heart disease and angina. However, there are huge differences between them. The two drugs have different mechanisms of action, so choosing one over the other is important to understand how effective these drugs are in treating various diseases.

esmolol vs labetalol vs metoprolol:

Esmolol is a beta-blocker, a drug used to treat high blood pressure and heart failure. Labetalol is the active ingredient in metoprolol. Effective against hypertension, heart failure and diabetic complications.

Esmolol is an alpha-1 adrenergic receptor agonist, while labetalol is an alpha-2 adrenergic receptor antagonist. Both drugs have been shown to help treat high blood pressure and congestive heart failure.

The same thing: Metoprolol and esmolol are both beta-blockers and both are used to treat high blood pressure. They have many effects on the body, such as antihypertensive, sedative, and bronchodilator.

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