Wholesale Factory Direct Enoxolone CAS 471-53-4

Silicon Dioxide
Factory Nano Silicon Dioxide Powder CAS 14808-60-7
Propylene Carbonate
Best Propylene Carbonate CAS 108-32-7

Name: Enoxolone

Cas: 471-53-4

Purity: 98.5%min


Directory Guidance on Enoxolone

Chemical Structure


Basic Info:

CAS No:471-53-4
Stock AvailabilityIn stock
Brand NameLook chem

Product Introduction:

Licorice (Glycyrrhize glabra L.) is a common medicinal and edible food.

The sweetness of licorice comes from Glycyrrhizic acid and Glycyrrhetinic acid (Enoxolone).

Licorice extract is widely used in candies and canned food as a natural sweetener.

Under normal conditions, it is a white crystalline powder with a sweet taste and the sweetness is about 200 times that of sucrose.

Different from the sweetness of sweeteners such as sucrose, Enoxolone takes a while to feel sweet after ingestion, but it lasts for a long time.

A small amount of glycyrrhizin and sucrose can be used together with 20% less sucrose and the sweetness remains unchanged.

Although Enoxolone Powder has no fragrance, it has the effect of enhancing fragrance.

Recent studies have shown that Glycyrrhizin and Enoxolone have certain anti-cancer and anti-cancer effects. Glycyrrhetinic acid can inhibit the information transmission and gene expression of primary cancer cells.

Glycyrrhizin has an inhibitory effect on the malignant tumors of experimental animals induced by a variety of carcinogens.

Enoxolone also has the effect of anti-viral infection, and inhibits the infection of carcinogenic viruses such as hepatitis virus, Epstein-Barr virus and HIV.

Nature and Specifications:

Product Packaging


Product Usage:

Use in food

  • Enoxolone powder can be used as sweetener, sweet taste improver, flavoring agent (applied in conjunction with table salt, the effect is particularly great) and flavor enhancer (dairy products, cocoa products, egg products, mutton, etc.) for removing mutton and enhancing flavor.
  • It is also used to flavor and mask the bitter taste of drugs such as aloe vera and quinine.

Use in medicine

  • Because of its anti-inflammatory and anti-allergic effects, and inhibiting bacterial reproduction, it can be used as an antibiotic medicine to treat infections such as Staphylococcus, Streptococcus, Escherichia coli, Helicobacter, etc.
  • This product can be used as an anti-inflammatory drug for the treatment of adrenal hypofunction, gastric and duodenal ulcers and other diseases.
  • It is effective in treating peptic ulcers and also has expectorant (antitussive) properties.

The Effect of Enoxolone:

Adrenal cortex hormone-like effect

  1. Mineralocorticoid-like effect
    • For healthy people and a variety of animals, Enoxolone can promote sodium, water retention, and increase in potassium excretion, presenting a deoxycorticosterone-like effect.
    • For patients whose adrenal glands on both sides are removed, 40 mg hydrocortisone intramuscularly injected daily for maintenance therapy, if glycyrrhetinic acid is added daily for 4 g subcutaneous injections, there will be a synergistic effect and electrolyte balance will be maintained.
    • However, if hydrocortisone is stopped and only Enoxolone is given, sodium storage capacity will be lost and Addison’s crisis will occur.
  2. Glucocorticoid-like effects
    • The chemical structure of glycyrrhetinic acid is similar to corticosteroids.
    • For animals with adrenal cortex removed and pituitary gland removed, glycyrrhetinic acid can still produce sodium retention and anti-diuretic and anti-inflammatory effects.
    • Another report pointed out that Enoxolone will have an effect on people with weakened adrenal cortex function but not complete failure.

Anti-inflammatory and anti-immune effects

  • Enoxolone has anti-inflammatory effects like phenylbutazone or hydrocortisone.
  • Its anti-inflammatory and anti-allergic reactions may be related to inhibiting capillary permeability, antihistamines or reducing cell response to stimuli.
  • Glycyrrhetinic acid has an inhibitory effect on a variety of acute inflammations. Its anti-inflammatory effect does not depend on the pituitary-adrenal cortex system, but is related to inhibiting the production of PgE2 in inflammatory tissues and antagonizing the inflammatory mediators histamine and serotonin.

The effect on the digestive system

  • Enoxolone can reduce blood bilirubin in rabbits and rats ligated to the common bile duct, and increase urinary bilirubin excretion. This effect is stronger than glucuronide or methionine.
  • It has a good anti-ulcer effect on rats with pyloric ligation, and its therapeutic index is higher.

Antitussive and antiphlegm effect

  • Enoxolone’s choline salt has a significant antitussive effect on the cough caused by chemical stimulation (inhalation of ammonia) and electrical stimulation of the cat’s superior laryngeal nerve.
  • Therefore, it is believed that the antitussive effect of Enoxolone is related to the central nervous system.

Anti-tumor effect

  • It has inhibitory effect on transplantation of Oberling-gnerin myeloma in rats.
  • When its sodium salt has the maximum tolerated dose, it can slightly inhibit the growth of mouse Ehrlich ascites carcinoma (FAC) and sarcoma-45 cells.

Antidiuretic effect

  • Enoxolone and its salts have obvious antidiuretic effects.
  • It can enhance the reabsorption of sodium and chloride in the renal tubules and present an antidiuretic effect.
  • Its mode of action is different from deoxycorticosterone, which may be its direct effect on renal tubules.

The effect on the auditory function of the inner ear

  • Using auditory electrophysiology methods, studies have shown that after intramuscular injection of glycyrrhetinic acid 100mg/kg in guinea pigs, the guinea pig auditory nerve action potential response threshold decreases, indicating that Enoxolone can improve the auditory function of the inner ear of guinea pigs.

Inhibition of acetylcholinesterase

  • When using glycyrrhetinic acid at a concentration of 4×10\-2mg/ml. It has a significant inhibitory effect on acetylcholinesterase, which is strengthened with the increase of drug concentration within this dose range.
  • Enoxolone’s inhibitory effect on acetylcholinesterase is a competitive-non-competitive mixed inhibition, which has a similar inhibitory effect to neostigmine.

Scavenge of oxygen free radicals

  • 18-β Glycyrrhetinic acid has a significant scavenging effect on O-2 and -OH produced by the aqueous system.
  • 30mol/L has a significant inhibitory effect on the chemiluminescence produced by PMN.
  • The results confirmed that 18-Beta glycyrrhetinic acid can directly capture oxygen free radicals.

Other functions

  1. Effect on estrogen
    • Enoxolone can inhibit the growth effect of estrogen on the uterus of juvenile animals, and it still has the same effect after removing the adrenal glands or ovaries.
  2. Antibacterial and antiviral effects
    • Glycyrrhetinic acid can enhance the effectiveness of berberine in inhibiting Staphylococcus aureus and neutralize the virulence of tetanus toxin.
  3. Impact on myocardial ischemia
    • Enoxolone can significantly counteract the changes in the electrocardiogram of rats with acute myocardial ischemia caused by pituitrin.

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