Domperidone
57808-66-9
Antioxidant 16831570-04-4
07/07/2020
Chlorinated paraffin
63449-39-8
28/06/2020
Domperidone paramete
| CAS No.: | 57808-66-9 |
| MF: | C22H24ClN5O2 |
| Place of Origin: | Shandong, China |
| Grade Standard: | Medicine Grade, Medicine Grade |
| Brand Name: | LOOK cas 57808-66-9 |
| Purity: | 99%min, 99.0%min |
| CAS: | 57808-66-9 |
| Packing: | 25kg/net drum or 1kg/aluminum foil bag |
| Solubility: | DMSO 40 mg/mL |
| form: | powder |
| Other Names: | Domperidone |
| EINECS No.: | 260-968-7 |
| Type: | Gastrointestinal Agents |
| Usage: | Animal Pharmaceuticals |
| Model Number: | ELLEN |
| Product name: | Domperidone |
| Color: | White powder |
| Molecular Weight: | 425.91 |
| Long-term Storage: | at -20℃ |
COA
| Items | Requirements | Results |
| Appearance | White to off white powder | White powder |
| Solubility | Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethanol(96%) and in methanol | Confirms |
| Identification | A. M.P. 244~248℃ | 244.5~245.5℃ |
| B. IR should comply | Confirms | |
| C. TLC should comply | Confirms | |
| D. It gives the reaction of non-nitrogen substituted barbiturates. | Confirms | |
| Clarity of solution | The solution is clear and not more intensely colored than reference solution Y6 | Confirms |
| Related substance | Total impurities≤0.5% | ≤0.29% |
|
Individual impurity≤0.25% |
≤0.18% | |
| Loss on drying | ≤0.5% | 0.07% |
| Sulphated ash | ≤0.1% | ≤0.05% |
| Heavy metal | ≤20ppm | <20ppm |
| Assay | 99.0%~101.0% |
99.49% |
| Items | Requirements | Results |
| Conclusion: This product conforms to the EP7.0 detection. | ||
Application
1.Used to treat dyspepsia and nausea and vomiting caused by functional, organic, infectious, dietary, radiotherapy or drug therapy
2. Gastrointestinal problems
There is some evidence that domperidone has antiemetic activity. Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting. It can be used in patients with Parkinson's disease because, unlike metoclopramide, domperidone does not cross the blood–brain barrier. Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated "for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis." The drug may also be used "to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents".
3.Lactation
The hormone prolactin stimulates lactation in humans, and its release is inhibited by the dopamine secreted by the hypothalamus. Domperidone, by acting as an anti-dopaminergic, results in increased prolactin secretion, and thus promotes lactation.
Packing Detail
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag). 2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)FAQ
Q1: Can I get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by customers.
Q2: How to start orders or make payments?
A : PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union LC,Alibaba trade assurance ,Moneygram.
Q3: What’s your MOQ?
A : Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q4: How about delivery leadtime?
A : Delivery lead time: About 3-5 days after payment confirmed.(Chinese holiday not included)
Q5: Is there a discount?
A : Different quantity has different discount.
Q6: How to contact us ?
A : You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.
Q7: How to confirm the Product Quality before placing orders?
A : You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Shipping
Logistics transportation methods can be divided into various ways according to the different transportation means.payment method:TT、LC、WU、Alibaba
Delivery Detail
within 3 days when get the payment .Video
Domperidone picture
Packaging and shipping
