Chlorpheniramine Maleate CAS 113-92-8

methanesulfonic acid
Methanesulfonic Acid CAS 75-75-2
27/04/2022
Dichloromethane
Dichloromethane CAS 75-09-2
25/04/2022
Chlorpheniramine maleate
113-92-8

Name: Chlorpheniramine Maleate

Cas: 113-92-8

Purity: 99%min

MOQ: 1KG

Basic Info:

CAS No:113-92-8
Formula:C20H23ClN2O4
EINECS:204-037-5
Stock AvailabilityIn stock
Brand NameLook chemical
OriginChina

Product Introduction:

Chlorpheniramine maleate, also known as chlorpheniramine, chlorpheniramine, chemical formula C16H19N2Cl. For allergic rhinitis, colds and sinusitis and allergic skin diseases such as urticaria, allergic drug eruption or eczema, angioedema, skin itching caused by insect bites, etc. When manufacturing medicines, its salt, chlorpheniramine maleate, is usually used.

Chlorpheniramine is a first-generation alkylamine antihistamine used to prevent symptoms of allergic diseases such as rhinitis and urticaria. It is less sedative than other first-generation antihistamines.

Chlorpheniramine is one of the most commonly used antihistamines in veterinary, small animals. Although not typically used as an antidepressant or anxiolytic, chlorpheniramine appears to have these properties, is a drug used for allergic symptoms, and belongs to the first generation of histamine H1 receptor antagonists (also known as antihistamines) .

Chlorpheniramine and ketotifen are both sedative antihistamines. Dermatologists like chlorpheniramine to treat allergic conditions like hives, and respiratory and pediatricians like ketotifen for asthma prevention and post-cold cough.

Nature and Specifications:

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Product Usage:

Chlorpheniramine maleate is mainly used for the production of antiallergic drugs, antihistamines, etc. Similar to clotrimide, brompheniramide is also an antihistamine. The production method of brompheniramine is also similar to that of clotrimide, except that the starting material is replaced by a bromobenzene compound.

The antihistamine effect of chlorpheniramine maleate is more than that of diphenhydramine and promethazine, with small dosage and mild side effects. For urticaria, vasodilatory rhinitis, colds, asthma, rhinitis, contact dermatitis, and also for allergies, insect bites and motion sickness caused by drugs and food.

Chlorpheniramine is an alkylamine antihistamine. It is characterized by strong antihistamine effect, small dosage and few side effects, and is suitable for children. Chlorpheniramine is one of the strongest antihistamines, its sedative effect is weaker than that of promethazine, and it also has a certain anticholinergic effect. It is used in combination with antipyretic analgesics to treat colds.

Indications and Pharmacological Effects of Chlorpheniramine Maleate:

Indications

Indications: Used for colds and allergic diseases of skin and mucous membranes. Its functions are mainly used for urticaria, eczema, dermatitis, drug eruption, skin pruritus, neurodermatitis, insect bites, solar dermatitis, and Chlorpheniramine maleate can also be used for allergic dermatitis, vasomotor rhinitis, drug and food allergies.

Chlorpheniramine maleate has a strong competitive blocking effect on histamine H1 receptors on allergy target cells, and plays an anti-allergic effect by antagonizing H1 receptors. It also has an anti-M choline receptor effect. Afterwards, symptoms such as dry mouth, constipation, thickened sputum, and dry nasal mucosa may occur.

Pharmacological Action

Chlorpheniramine maleate is an H1 receptor antagonist, and its chemical structure is a hydrocarbon amine. It can mainly competitively block histamine H1 receptors on allergy target cells, so that histamine cannot bind to H1 receptors, thereby inhibiting the allergic reactions caused by it. But chlorpheniramine does not affect the metabolism of histamine, nor does it prevent the release of histamine in the body.

Chlorpheniramine also has central inhibitory and anticholinergic effects, so after taking the drug, there will be drowsiness, dry mouth, constipation, thickened sputum and dry nasal mucosa. After long-term clinical practice, it is believed that chlorpheniramine has strong antihistamine effect, small dosage and small side effects.

Chlorpheniramine still has the effect of reducing tracheal secretion and gastric acid secretion. Before the advent of a new generation of antihistamines, it was the most commonly used antihistamine in clinical practice.

Medicine Interactions

  1. Chlorpheniramine maleate in combination with alcohol and other central nervous system depressants, such as barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antiepileptic drugs, can increase the central nervous system inhibitory effect of antihistamines, but This interaction is weaker with newer antihistamines.
  2. Combination with other anticholinergic drugs, such as atropine, tricyclic antidepressants and monoamine oxidase inhibitors, can enhance the anticholinergic effect of these drugs.
  3. When some antihistamines metabolized by the liver are combined with liver drug enzyme inhibitors, adverse reactions may increase.
  4. Some antihistamines may mask the toxicity symptoms of certain ototoxic drugs, such as aminoglycoside antibiotics.
  5. Antihistamines can inhibit the skin test reaction of allergenic substances, so all antihistamines should be stopped several days before the skin test to avoid affecting the skin test results.
  6. Combination of this product with phenytoin may inhibit its liver metabolism and increase its toxicity, so the concentration of phenytoin should be monitored.
  7. Chlorpheniramine maleate can enhance the effects of amantadine, anticholinergics, haloperidol, phenothiazines and sympathomimetic drugs.
  8. Drinking alcohol or taking central nervous system depressants at the same time can enhance the efficacy of this product.

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