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Chloroquine diphosphate, also referred to as chloroquine phosphate, is a 4-aminoquinoline antimalarial medicine. It can prevent the nucleic acid synthesis of Plasmodium schizonts, disrupt the growth and recreation of Plasmodium, and has a high-efficiency murder impact on Plasmodium schizonts.
is a substrate of MRP in multidrug-resistant cell lines and inhibits photoaffinity labeling of MRP by the quinoline-based photoactive drug IAAQ.
This product is white crystalline powder, odorless and bitter in taste. When exposed to light, the color changes, and the aqueous solution exhibits an acidic reaction. Soluble in water, almost insoluble in ethanol, chloroform and ether.
Oral administration of chloroquine diphosphate is fast and sufficient, with slow excretion and metabolism, long-lasting effect and low toxicity. Also has anti-tissue enamoeba effects.
The latest research shows that chloroquine diphosphate has a certain inhibitory effect on the new coronavirus pneumonia (COVID-19).
Chloroquine is known not to kill the malaria parasite directly, but to interfere with its reproduction. Chloroquine can fragment the nuclei of Plasmodium, vacuoles appear between cells, and malaria pigments aggregate into clumps.
Its mechanism of action is that chloroquine diphosphate has a strong binding force with nucleoprotein, and the negatively charged 7-chloro group on its quinoline ring is close to the 2-amino group on DNA guanine, so that chloroquine is inserted into the double helix of DNA. between shares.
Chloroquine diphosphate develops a facility with DNA, consequently protecting against DNA duplication and also RNA transcription. Chloroquine can also prevent the consolidation of phosphoric acid right into the DNA and also RNA of Plasmodium, which disrupts the recreation of Plasmodium as a result of the decrease of nucleic acid synthesis.
Additionally, chloroquine diphosphate can conflict with the entry of fatty acids right into phospholipids and control glutamate dehydrogenase and hexokinase. Chloroquine mainly acts on schizonts in the red inner stage. After 48 to 72 hours, the schizonts in the blood are killed.
This product has no impact on the infrared stage of vivax malaria, so it can not eliminate vivax jungle fever. falciparum malaria can be removed.
Chloroquine diphosphate is mainly used in the production of anti-malarial drugs for the treatment of malaria and inflammation.
For malaria treatment:
For inflammation treatment:
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