Chloroquine Diphosphate CAS 50-63-5

Sodium Stearate
Sodium stearate
Pyroxasulfone Herbicide
Pyroxasulfone Herbicide CAS 447399-55-5
Chloroquine Diphosphate

Name: Chloroquine Diphosphate

Cas: 50-63-5

Purity: 99%min


Directory Guidance on Chloroquine Diphosphate

Chemical Structure

Chloroquine Diphosphate

Basic Info:

CAS No:50-63-5
Stock AvailabilityIn stock
Brand NameLook chemical

Product Introduction:

Chloroquine diphosphate, also referred to as chloroquine phosphate, is a 4-aminoquinoline antimalarial medicine. It can prevent the nucleic acid synthesis of Plasmodium schizonts, disrupt the growth and recreation of Plasmodium, and has a high-efficiency murder impact on Plasmodium schizonts.

is a substrate of MRP in multidrug-resistant cell lines and inhibits photoaffinity labeling of MRP by the quinoline-based photoactive drug IAAQ.

This product is white crystalline powder, odorless and bitter in taste. When exposed to light, the color changes, and the aqueous solution exhibits an acidic reaction. Soluble in water, almost insoluble in ethanol, chloroform and ether.

Oral administration of chloroquine diphosphate is fast and sufficient, with slow excretion and metabolism, long-lasting effect and low toxicity. Also has anti-tissue enamoeba effects.

The latest research shows that chloroquine diphosphate has a certain inhibitory effect on the new coronavirus pneumonia (COVID-19).

Nature and Specifications:

Product Packaging


Pharmacological Effects of Chloroquine Diphosphate:

Chloroquine is known not to kill the malaria parasite directly, but to interfere with its reproduction. Chloroquine can fragment the nuclei of Plasmodium, vacuoles appear between cells, and malaria pigments aggregate into clumps.

Its mechanism of action is that chloroquine diphosphate has a strong binding force with nucleoprotein, and the negatively charged 7-chloro group on its quinoline ring is close to the 2-amino group on DNA guanine, so that chloroquine is inserted into the double helix of DNA. between shares.

Chloroquine diphosphate develops a facility with DNA, consequently protecting against DNA duplication and also RNA transcription. Chloroquine can also prevent the consolidation of phosphoric acid right into the DNA and also RNA of Plasmodium, which disrupts the recreation of Plasmodium as a result of the decrease of nucleic acid synthesis.

Additionally, chloroquine diphosphate can conflict with the entry of fatty acids right into phospholipids and control glutamate dehydrogenase and hexokinase. Chloroquine mainly acts on schizonts in the red inner stage. After 48 to 72 hours, the schizonts in the blood are killed.

This product has no impact on the infrared stage of vivax malaria, so it can not eliminate vivax jungle fever. falciparum malaria can be removed.

Product Usage:

Chloroquine diphosphate is mainly used in the production of anti-malarial drugs for the treatment of malaria and inflammation.

For malaria treatment:

  • Chloroquine diphosphate can be made use of for the therapy of chloroquine-sensitive Plasmodium falciparum, Plasmodium vivax as well as Plasmodium jungle fever. As well as can be made use of for suppressive prevention of jungle fever symptoms.
  • It is used to make antimalarial drugs, control malaria symptoms, control and prevent malaria symptoms and amoebic liver abscesses.
  • It can additionally be utilized to deal with extraintestinal amebiasis, connective tissue disease, photosensitivity illness (such as sunburn erythema), and so on.
  • This product also has anti-paragonimiasis and clonorchiasis, anti-leishmaniasis and expelling tapeworms, cysticercosis and quinidine-like effects.
  • Chloroquine diphosphate is also effective against photosensitivity diseases.

For inflammation treatment:

  • Chloroquine diphosphate has an immunosuppressive effect, which can inhibit lymphocyte transformation, reduce the number of T cells in the blood circulation, block the formation of immune complexes, stabilize lysosomal membranes and prevent the synthesis of prostaglandins.
  • Can be used for rheumatoid arthritis, lupus erythematosus, nodular periarteritis, dermatomyositis, scleroderma, chronic nephritis, etc.
  • Chloroquine diphosphate is also used for the anti-relapse treatment of chronic bronchitis. No abortifacient, can be used for pregnant women.

Related References:

  1. Ehiemua, A.O., Komolafe, O.O., Oyedeji, G.A. et al. Effect of promethazine on the metabolism of chloroquine. European Journal of Drug Metabolism and Pharmacokinetics 13, 15–17 (1988).
  2. Bajpai J, Pradhan A, Singh A, Kant S. Hydroxychloroquine and COVID-19 – A narrative review. Indian J Tuberc. 2020 Dec;67(4S):S147-S154. doi: 10.1016/j.ijtb.2020.06.004. Epub 2020 Jul 3. PMID: 33308661; PMCID: PMC7836863.
  3. Wikipedia

Our Promise:

Loading and Transportation

Contact us for the latest quotation and free samples of Chloroquine Diphosphate Powder

Send Inquiry

Hot Products