Chloroquine Diphosphate CAS 50-63-5
Sodium stearate
822-16-2
05/09/2022
Pyroxasulfone Herbicide CAS 447399-55-5
26/08/2022
Name: Chloroquine Diphosphate
Cas: 50-63-5
Purity: 99%min
MOQ: 1KG
Directory Guidance on Chloroquine Diphosphate
- Basic Information of Chloroquine Diphosphate
- What is Chloroquine Diphosphate?
- The Nature and Specifications of Chloroquine Phosphate
- Pharmacological Effects of Chloroquine Diphosphate
- What Are The Uses of Chloroquine Diphosphate?
- Related References
- Our Promise
- Loading and Transportation
- Hot Products
Chemical Structure
Basic Info:
| CAS No: | 50-63-5 |
| Formula: | C18H32ClN3O8P2 |
| EINECS: | 200-055-2 |
| Stock Availability | In stock |
| Brand Name | Look chemical |
| Origin | China |
Product Introduction:
Chloroquine diphosphate, also referred to as chloroquine phosphate, is a 4-aminoquinoline antimalarial medicine. It can prevent the nucleic acid synthesis of Plasmodium schizonts, disrupt the growth and recreation of Plasmodium, and has a high-efficiency murder impact on Plasmodium schizonts.
is a substrate of MRP in multidrug-resistant cell lines and inhibits photoaffinity labeling of MRP by the quinoline-based photoactive drug IAAQ.
This product is white crystalline powder, odorless and bitter in taste. When exposed to light, the color changes, and the aqueous solution exhibits an acidic reaction. Soluble in water, almost insoluble in ethanol, chloroform and ether.
Oral administration of chloroquine diphosphate is fast and sufficient, with slow excretion and metabolism, long-lasting effect and low toxicity. Also has anti-tissue enamoeba effects.
The latest research shows that chloroquine diphosphate has a certain inhibitory effect on the new coronavirus pneumonia (COVID-19).
Nature and Specifications:
Product Nature
Specification
Product Nature
- Boiling point: 460.6ºC at 760 mmHg
- Melting point: 200 °C (dec.) (lit.)
- Flash point: 232.3ºC
- Solubility: H2O: 50 mg/mL, clear
- PH value: 3.8～4.3 (100g/l, 25℃)
- Storage conditions: protect from light
Specification
| Item | Specification |
| Product Name | Chloroquine Diphosphate Powder |
| CAS No. | 50-63-5 |
| Appearance | White crystalline powder |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
Product Packaging
Previous
Next
Pharmacological Effects of Chloroquine Diphosphate:
Chloroquine is known not to kill the malaria parasite directly, but to interfere with its reproduction. Chloroquine can fragment the nuclei of Plasmodium, vacuoles appear between cells, and malaria pigments aggregate into clumps.
Its mechanism of action is that chloroquine diphosphate has a strong binding force with nucleoprotein, and the negatively charged 7-chloro group on its quinoline ring is close to the 2-amino group on DNA guanine, so that chloroquine is inserted into the double helix of DNA. between shares.
Chloroquine diphosphate develops a facility with DNA, consequently protecting against DNA duplication and also RNA transcription. Chloroquine can also prevent the consolidation of phosphoric acid right into the DNA and also RNA of Plasmodium, which disrupts the recreation of Plasmodium as a result of the decrease of nucleic acid synthesis.
Additionally, chloroquine diphosphate can conflict with the entry of fatty acids right into phospholipids and control glutamate dehydrogenase and hexokinase. Chloroquine mainly acts on schizonts in the red inner stage. After 48 to 72 hours, the schizonts in the blood are killed.
This product has no impact on the infrared stage of vivax malaria, so it can not eliminate vivax jungle fever. falciparum malaria can be removed.
Product Usage:
Chloroquine diphosphate is mainly used in the production of anti-malarial drugs for the treatment of malaria and inflammation.
For malaria treatment:
- Chloroquine diphosphate can be made use of for the therapy of chloroquine-sensitive Plasmodium falciparum, Plasmodium vivax as well as Plasmodium jungle fever. As well as can be made use of for suppressive prevention of jungle fever symptoms.
- It is used to make antimalarial drugs, control malaria symptoms, control and prevent malaria symptoms and amoebic liver abscesses.
- It can additionally be utilized to deal with extraintestinal amebiasis, connective tissue disease, photosensitivity illness (such as sunburn erythema), and so on.
- This product also has anti-paragonimiasis and clonorchiasis, anti-leishmaniasis and expelling tapeworms, cysticercosis and quinidine-like effects.
- Chloroquine diphosphate is also effective against photosensitivity diseases.
For inflammation treatment:
- Chloroquine diphosphate has an immunosuppressive effect, which can inhibit lymphocyte transformation, reduce the number of T cells in the blood circulation, block the formation of immune complexes, stabilize lysosomal membranes and prevent the synthesis of prostaglandins.
- Can be used for rheumatoid arthritis, lupus erythematosus, nodular periarteritis, dermatomyositis, scleroderma, chronic nephritis, etc.
- Chloroquine diphosphate is also used for the anti-relapse treatment of chronic bronchitis. No abortifacient, can be used for pregnant women.
Related References:
- Ehiemua, A.O., Komolafe, O.O., Oyedeji, G.A. et al. Effect of promethazine on the metabolism of chloroquine. European Journal of Drug Metabolism and Pharmacokinetics 13, 15–17 (1988).
- Bajpai J, Pradhan A, Singh A, Kant S. Hydroxychloroquine and COVID-19 – A narrative review. Indian J Tuberc. 2020 Dec;67(4S):S147-S154. doi: 10.1016/j.ijtb.2020.06.004. Epub 2020 Jul 3. PMID: 33308661; PMCID: PMC7836863.
- Wikipedia
Our Promise:
Achievements
Service
FAQ
Advice on Shipping
Achievements
I’m william, CEO of Look Chemical Co., Ltd. Welcome to visit our company. As China’s top Global Supply Specialist of chemicals, we have always been adhering to the principle of “service first, quality first, mutual benefit”, and we insist on Create value for customers and grow together with customers.
In the past few years , we have provided efficient and satisfactory services to more than 6000 customers and have been widely praised internationally. In the future, we will strive to provide more than 100,000 customers with professional and thoughtful services, and strive to become your first choice for worry-free purchasing chemicals in China , Hope to bring you a good cooperation experience. If you have any questions, please feel free to contact us.
Service
Pre-Sales Service
* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.
* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
After-Sales Service
*We will monitor the logistics information in real time and will share the information with you.
* You can consult us at any time if you have any questions about the product, and we will answer you in time.
*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
