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acetylsalicylic acid (abbreviation: ASA), also known as Aspirin, is a white crystal or crystalline powder.
Odorless or slightly acetic acid odor, slightly soluble in water, easily soluble in ethanol, soluble in ether and chloroform, the aqueous solution is acidic.
Acetylsalicylic Acid is a derivative of salicylic acid. After nearly a hundred years of clinical application, it has been proved that it can relieve mild or moderate pain. It was first used for anti-inflammatory and analgesic.
Such as toothache, headache, neuralgia, muscle pain and dysmenorrhea, it has better effect.
In recent years, it has been discovered that Acetylsalicylic Acid can inhibit platelet aggregation and protect against thrombosis. It is medically utilized to stop transient ischemic strike, myocardial infarction, man-made heart shutoff and venous fistula or other postoperative thrombosis.
As the research on aspirin continues to deepen, many new uses have been discovered. For example, aspirin can reduce myocardial infarction and stroke mortality, and can also reduce the risk of colorectal cancer.
Acetylsalicylic Acid is one of the most widely used drugs in the world today, with an annual consumption of approximately 40,000 metric tons.
This product is listed in the WHO Model List of Essential Medicines and is one of the essential medicines for the basic public health system.
Acetylsalicylic Acid is mainly used in the pharmaceutical industry, and is the earliest, most widely used and most common antipyretic, analgesic and antirheumatic drug.
Acetylsalicylic Acid has various pharmacological effects such as antipyretic, analgesic, anti-inflammatory, anti-wind and anti-platelet aggregation.
Commonly used for cold and fever, headache, neuralgia, arthralgia, muscle pain, rheumatic fever, acute rheumatoid arthritis, rheumatoid arthritis and toothache.
Acetylsalicylic Acid is used to promote the excretion of uric acid in patients with gout, anti-platelet aggregation and treatment of biliary ascaris.
Acetylsalicylic acid (aspirin) has antithrombotic properties in the body and reduces the formation of obstructive thrombi in peripheral arteries.
Inhibits the release of platelets and the release of endogenous ADP, 5-HT, etc.
Thus, aggregation of the second phase of platelets is inhibited without inhibiting aggregation of its first phase.
The mechanism of action of acetylsalicylic acid (aspirin) is to acetylate the cyclooxygenase of platelets, thereby inhibiting the formation of intracyclic peroxides and reducing the production of TXA2.
At the same time, it can also acetylate platelet membrane proteins and inhibit platelet membrane enzymes, which also helps to inhibit platelet function.
It can also inhibit the enzyme of platelet TXA2 synthesis. For example, in large doses, the production of TXA2 and PGI2 is affected.
It is suitable for ischemic heart disease, after coronary angioplasty (PTCA), and after coronary artery bypass grafting. It can avoid short-term analytical anemia, stroke, heart attack, and lower the incidence of arrhythmia.
Acetylsalicylic Acid has an inhibitory result on platelet gathering, so the signs for aspirin enteric-coated tablets are as adheres to:
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