6-Fluoronicotinic Acid (CAS 403-45-2) Supplier | High Purity Grade | SD Look Chem
6-Fluoronicotinic acid CAS 403-45-2 | Pharmaceutical Intermediates
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Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
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Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
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Min: 10 Gram
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Delivery: 7 Days
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Transporta: Ocean, Land,Air, DHL，TNT
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Port: Shanghai Port, Qingdao Port
Name: 6-Fluoronicotinic acid
CAS: 403-45-2
Purity: 99%min
MOQ: 1KG
Chemical Structure
Basic Info:
| CAS No: | 403-45-2 |
| Name: | 6-Fluoronicotinic acid |
| EINECS: | 251-228-4 |
| Formula: | C6H4FNO2 |
| Weight: | 141.1 |
| Other Names: | 2-Fluoropyridine-5-carboxylic acid |
| Type: | Pharmaceutical Intermediates |
| Shelf Life: | 1 years |
| Brand Name: | Look Chem |
| Place of Origin: | Shandong, China |
Basic Introduction to 6-Fluoronicotinic acid
6-Fluoronicotinic acid (IUPAC Name: 2-Fluoro-5-pyridinecarboxylic acid, CAS No. 403-45-2) is a white to off-white crystalline solid belonging to the specialized class of fluorinated pyridine derivatives. The strategic introduction of a fluorine atom at the C-6 position of the nicotinic acid core drastically alters the electron density of the pyridine ring, enhancing metabolic stability, lipophilicity, and binding affinity in downstream target molecules.
To address the stringent purity demands of active pharmaceutical ingredient (API) manufacturers and agrochemical innovators, Shandong Look Chemical Co., Ltd. produces standardized, high-assay 6-Fluoronicotinic acid. Functioning as a versatile halogenated heterocycle synthon, it serves as a critical structural moiety in cross-coupling reactions, amide couplings, and nucleophilic aromatic substitution (SNAr) processes. Our controlled fluorination process eliminates unwanted regioisomers and unreacted starting materials, delivering consistency across commercial batches.
Nature and Specifications:
Specification
Specification
| Item | Specification |
| Product Name | 6-Fluoronicotinic acid |
| CAS No. | 108-46-3 |
| Appearance | Powder Crystal |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
Product Packaging
6-Fluoronicotinic acid Application
The unique electronic profile of 6-Fluoronicotinic acid makes it a vital intermediate across demanding fine chemical domains:
A. Active Pharmaceutical Ingredient (API) Synthesis
In modern medicinal chemistry, 6-Fluoronicotinic acid serves as a specialized building block:
Kinase Inhibitor & Receptor Modulator Synthesis: The 6-fluoropyridine-3-carbonyl framework is frequently incorporated into small-molecule kinase inhibitors, oncological agents, and central nervous system (CNS) modulators to enhance target selectivity.
Amide Coupling Reactions: The carboxylic acid group readily reacts with primary or secondary amines to construct functional carboxamide linkages under standard coupling reagents (e.g., HATU, EDC·HCl).
B. Agrochemical Innovations
Novel Crop Protection Compounds: Serves as a key intermediate for synthesizing high-efficiency herbicides, insecticides, and fungicides. The fluorinated core imparts increased metabolic persistence in plants and enhanced target-organism bio-efficacy.
C. Specialty Fluorinated Intermediates
Nucleophilic Substitution Reactions: The electron-deficient C-6 position activated by the fluorine atom enables nucleophilic displacement by alkoxides, primary amines, or thiols, yielding diverse 6-substituted nicotinic acid derivatives.
Certifications & Regulatory Compliance
To facilitate smooth cross-border customs clearance and support our clients’ regulatory filings across Europe, North America, and Asia, our manufacturing workflows operate under established quality and compliance frameworks:
ISO 9001:2015 Quality Management System: Standardized synthesis protocols ensuring lot-to-lot chemical reproducibility and strict impurity threshold management.
ISO 14001:2015 Environmental Management System: Responsible fluorination chemistry adhering to sustainable waste treatment, scrubbed off-gas management, and eco-conscious discharge limits.
GHS & SDS Compliance: Standard 16-section Safety Data Sheets compiled according to global GHS criteria, providing hazard classification, handling, and spill control guidelines.
REACH Compliance Support: Complete technical documentation and registration support for seamless regulatory acceptance within European Union markets.
Standardized Packaging Compliance: UN-tested moisture-proof fiber drums with double-layer PE inner liners, designed to preserve compound integrity during long-distance international transit.
At SD Look Chemical, quality control precedes dispatch. Every production batch of 6-Fluoronicotinic acid undergoes multi-dimensional testing in our analytical laboratory to verify its structural identity and purity profile before inventory release.
Typical Certificate of Analysis (COA) Specifications:
Appearance: White to off-white crystalline powder (Conforms / Visual Inspection)
Identification (1H-NMR & FT-IR): Conforms to standard spectrum (Conforms)
Purity / Assay (HPLC): ≥ 98.5 % (Typical Result: 99.20 % / HPLC-UV at 254 nm)
Individual Related Impurities: ≤ 0.50 % (Typical Result: 0.15 % / HPLC)
Loss on Drying: ≤ 0.50 % (Typical Result: 0.22 % / Vacuum Drying Oven)
Melting Point Range: 146°C – 150°C (Typical Result: 147.5°C – 149.0°C / Melting Point Apparatus)
Ignition Residue (Sulfated Ash): ≤ 0.20 % (Typical Result: 0.08 % / Gravimetric Analysis)
High-Performance Liquid Chromatography (HPLC-UV): Quantitative evaluation of purity and strict profiling of regioisomeric and organic impurities.
Nuclear Magnetic Resonance (1H-NMR / 19F-NMR): Confirms regioselective fluorination at the C-6 position, excluding C-2 or C-4 fluorinated isomers.
Loss on Drying & Ash Content Testing: Ensures low moisture levels to prevent hydrolytic interference during subsequent amide coupling or organometallic functionalization.
Lot Sample Retention Protocol: Representative samples from every commercial lot are cataloged and stored in climate-monitored retention archives for 24 months to ensure post-delivery traceability.
FAQ
A: We supply standard High-Purity Synthesis Grade (Assay ≥98.5% by HPLC) as our regular commercial offer. For specialized pharmaceutical applications requiring tighter controls on specific organic impurities or tighter moisture limits, our R&D team can adjust parameters according to technical agreements.
A: 6-Fluoronicotinic acid should be stored in tightly sealed containers in a dry, cool, and well-ventilated area, protected from direct sunlight and humidity. When handled under cool, dry conditions, the product maintains long-term chemical stability.
A: Yes. We provide sample quantities (ranging from 10g to 1kg) for R&D teams and analytical testing. Commercial quantities are available in 25kg fiber drums or custom packaging configurations based on order volume.
A: Every dispatched order is accompanied by a batch-specific Certificate of Analysis (COA) and a compliant Safety Data Sheet (SDS). Additional technical data, including NMR spectra, HPLC chromatograms, and TDS, can be supplied upon technical request to support customer vendor audit procedures.
Related References:
Pubchem–6-Fluoronicotinic acid
6-Fluoronicotinic acid Manufacturer & Supplier
As an experienced producer and supplier of 6-Fluoronicotinic acid, Look Chemical is committed to producing and selling high-quality products.
We cooperate and trade with over 6000 factories worldwide, and our high-quality products and services have earned us a high reputation internationally.
As a supplier of 6-Fluoronicotinic acid, Look Chemical provides supply chain solutions to partners and customers in various industries. We offer highly competitive prices and high-quality products.
If you have a demand for this product, please contact our sales staff and we will provide you with a solution as soon as possible.
Achievements📝
I’m william, CEO of Look Chemical Co, Ltd. Welcome to visit our company. As China’s top Global Supply Specialist of chemicals, we have always been adhering to the principle of “service first, quality first, mutual benefit”, and we insist on Create value for customers and grow together with customers.
In the past few years , we have provided efficient and satisfactory services to more than 6000 customers and have been widely praised internationally. In the future, we will strive to provide more than 100,000 customers with professional and thoughtful services, and strive to become your first choice for worry-free purchasing chemicals in China , Hope to bring you a good cooperation experience. If you have any questions, please feel free to contact us.
Pre-Sales Service👍
* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.
* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
After-Sales Service🔔
*We will monitor the logistics information in real time and will share the information with you.
* You can consult us at any time if you have any questions about the product, and we will answer you in time.
*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.
Advice on Shipping✈️
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Look chemical company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 30,000 products with the best quality and competitive price to meet your different purchasing needs.
Product Data:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Analysis (MOA)
- Nuclear Magnetic Resonance (NMR)
- Packing pictures and loading video before loading
- Free Sample
- Factory audit
