2,6-Dimethylpyrazine CAS 108-50-9

2,6-Dimethylpyrazine CAS 108-50-9
2,6-Dimethylpyrazine CAS 108-50-9

Name:2,6-Dimethylpyrazine

CAS: 108-50-9

Purity: 99%min

MOQ: 1KG

Directory Guidance on 2,6-Dimethylpyrazine

Chemical Structure

2,6-Dimethylpyrazine CAS 108-50-9

Basic Info:

CAS No:108-50-9
Name:2,6-Dimethylpyrazine
EINECS:203-589-4
Formula:C6H8N2
Weight:108.14
Other Names:2,6-dimethyl-pyrazin
Type:Organic raw materials
Shelf Life:2 years
Brand Name:Look Chem
Place of Origin:Shandong, China

Product Introduction:

2,6-Dimethylpyrazine is a typical class of pyrazine heterocyclic compounds (also common synonym 3,5-dimethylpyrazine under different numbering systems), molecular formula C₆H₈N₂, molecular weight 108.14. It mostly behaves as solid or near low-melting point crystalline state at room temperature, common reference melting point range in commercial materials is about 35–43°C (specifically depending on purity and test method), atmospheric boiling point about 154–155°C. Public specifications usually describe it as soluble in water, meanwhile having good solubility and compatibility in common organic solvents like ethanol, ether, etc. For purchasers, this physical characteristic means it is relatively convenient in pre-dissolving and dispersing operations of water-based or alcohol-based systems, and formula adaptability is strong.

As a high-purity edible flavor and organic synthesis raw material, it is not only an important component in food industry simulating coffee, chocolate, peanut and fried food flavors, but also a useful synthetic block in fine chemical field. For buyers, understanding its value lies in how it brings significant flavor improvement to your final product with lower addition amount.

Nature and Specifications:

Product Packaging

2,6-Dimethylpyrazine Uses:

This is the most main application field of 2,6-Dimethylpyrazine. It is widely used to blend various flavors needing to express “high temperature processing” characteristics.

Coffee and Drinks Flavoring: Whether in instant coffee, canned coffee drinks, or coffee flavored dairy products, 2,6-Dimethylpyrazine helps to reproduce roasting aroma. It can modify top notes lost during processing, bringing pleasant burnt aroma and cocoa undertone.

Chocolate and Candy: In chocolate products, it can enhance roasting sense of cocoa beans, make sweetness no longer monotonous, increase flavor layers. In toffee, caramel flavored candies, it is a common raw material building nut aroma base.

Baking Foods and Nut Processing: In flavoring of biscuits, bread, cakes and roasted seeds and nuts (like peanuts, melon seeds), this raw material is often used to reinforce fresh baking sense. Especially for low-fat or non-fried products, adding appropriate amount of 2,6-Dimethylpyrazine can assist to simulate aroma characteristics peculiar to fried foods.

Savory Foods and Meat Products: In meat flavors (especially beef and pork flavors) and seasoning powders of leisure foods (like potato chips, puffed foods), it provides specific meat aroma and grease aroma produced after frying, roasting, deep-frying, and is an important supplement to Maillard reaction flavor.

Besides being used as flavor, 2,6-Dimethylpyrazine is also a flexible intermediate in organic synthesis chemistry.
Construction of Functional Molecules: Due to structural characteristics of pyrazine ring, it can be used as nitrogen-containing heterocyclic raw material for further functionalization. Downstream partial fine chemicals or special materials may use it as starting material for structural modification.
Coordination Chemistry: In certain chemical researches, dimethylpyrazine derivatives also can serve as ligands to participate in coordination reactions.

In traditional tobacco flavoring field, it is often used to promote mellowness of smoke, increasing aftertaste similar to nuts or cocoa. Need to note is, for blending of inhalation products like electronic vaping liquid, although it has function of providing baking base note, but because this substance usually contains respiratory irritation related tips (like H335) in SDS, enterprises need to strictly follow regulations of target market and conduct sufficient safety assessment.

The Advantages of 2,6-Dimethylpyrazine

2,6-Dimethylpyrazine possesses lower Sensory Threshold (namely high sensitivity). This means less addition amount (usually at ppb–ppm level) can produce significant aroma effect. For manufacturers, this means higher cost efficiency — raw material usage efficiency is high, cost distributed to single terminal product is relatively controllable.

In food processing processes like baking, high temperature sterilization or extrusion puffing, many volatile aroma components are easy to lose. 2,6-Dimethylpyrazine shows relatively good chemical stability. It can, in heating processing environment of certain degree, assist product to retain baking aroma, which has positive significance for flavor maintenance of pre-packaged foods.

Although this is a monomer flavor, but its aroma characteristic is close to products of natural Maillard Reaction. When it is reasonably compounded with other fragrance raw materials (like vanillin, furanone, etc.), it usually can reduce abruptness of single raw material, promote realism and fullness of overall flavor.

In markets like USA, 2,6-Dimethylpyrazine is usually listed as flavor substance in FEMA (Flavor and Extract Manufacturers Association) list (FEMA No. 3273) and JECFA (Joint FAO/WHO Expert Committee on Food Additives) assessment. This clear compliance information makes food enterprises can use under premise of complying with local regulations.

Industry Q & A

A: Although they are all isomers of dimethylpyrazine, but aroma characteristics have slight emphasis, and are very sensitive to base:
2,6-Dimethylpyrazine (CAS 108-50-9): Aroma is usually described as leaning towards fried nuts, peanut, coffee and cocoa, bringing a kind of “dry” baking sense and fried potato-like breath.
2,3-Dimethylpyrazine: Aroma of this isomer is often described as leaning towards caramel, cocoa, sometimes carrying heavier burnt or green breath.
2,5-Dimethylpyrazine: Aroma carries obvious chocolate, roasted nut taste, sometimes also described having earthy taste or raw potato taste. Suggestion: If your product focuses on expressing crisp nut aroma, coffee aroma or fried food aroma, 2,6-isomer is usually common choice. Many high-grade formulas will use these several isomers simultaneously through experiment to build complex layering.

A: Melting point of 2,6-Dimethylpyrazine is usually between 35°C to 43°C (depending on specific specifications). This leads to its state at room temperature depending on environmental temperature. In summer or warm environment, it may appear as liquid or partial molten state. In winter or air-conditioned room, it usually solidifies into white crystalline solid. This is normal physical phenomenon. If solid is received, just heat in mild water bath (suggest not exceeding 50-60°C) to make it melt and shake well then can be used.

A: The standard industrial grade and food grade 2,6-Dimethylpyrazine we supply, purity is usually controlled above 99.0% (GC). For vast majority of flavor fragrance applications and organic synthesis applications, 99% purity is already enough to help purity of aroma and accuracy of reaction.

A: This product should be stored in cool, dry, well-ventilated place, away from fire source and heat source. Because it may be relatively sensitive to air and light, must keep container sealed. During transportation, this substance usually contains hazard information like Flammable Solid (H228) in SDS/GHS; transportation information is commonly UN1325 (Class 4.1) or related categories (subject to that batch SDS/SDS transportation section).

A: As nitrogen-containing heterocyclic compound, its pyrazine ring and side chain methyl have certain chemical activity, can be used for further functionalization and derivatization (like oxidation or side chain modification). For fine chemical customers, we suggest conducting reaction assessment under suitable laboratory conditions according to target synthesis route.

A: In order to support your R&D and testing, we are usually happy to provide small specification samples. For formal orders, MOQ depends on specific packaging form and inventory situation (like common 1kg aluminum bottle or 25kg drum packing). We will provide corresponding quotation and service according to your actual demand.

A: Commercial large-scale supply of 2,6-Dimethylpyrazine is mostly made by chemical synthesis (its chemical structure is consistent with similar substances existing in natural foods). This guarantees stability of supply and controllability of cost. If your product must claim “Natural Flavoring“, then need to specially look for products complying with specific regulation definitions (like through biological fermentation or extraction), and cost and supply situation will have great difference.

A: This depends on the country you are in and usage. Usually, purchasing as food additive or flavor, we need you to provide corresponding enterprise qualifications. If used for industrial synthesis or laboratory research, may need to provide usage description, to ensure compliance. We will assist you to prepare standard documents like export required SDS (Safety Data Sheet), COA (Certificate of Analysis) etc.

Related References:

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