| CAS No: | 123-32-0 |
| Name: | 2,5-Dimethyl Pyrazine |
| EINECS: | 204-618-3 |
| Formula: | C6H8N2 |
| Weight: | 108.14 |
| Other Names: | 2,5-Dimethylprazin |
| Type: | Flavors and fragrances |
| Shelf Life: | 2 years |
| Brand Name: | Look Chem |
| Place of Origin: | Shandong, China |
2,5-Dimethylpyrazine (CAS 123-32-0) is a typical nitrogen-containing heterocyclic aromatic compound with the molecular formula C₆H₈N₂ and a molecular weight of 108.14. At room temperature (about 20–25°C), it is mostly a colorless to pale yellow transparent liquid; at low temperatures approaching the melting point, crystallization or thickening phenomena may occur. It carries obvious odor characteristics of roasting, nuts, and cocoa/coffee baking types. This kind of “roasted feeling” odor does not appear out of thin air; it is common and consistent in odor performance with the Maillard reaction products (pyrazine substances) common when food is heated, so it is very recognizable in the flavor system.
From a procurement perspective, the value of 2,5-Dimethylpyrazine lies in: in most flavor systems, it is usually used at a lower ratio for “bottoming/contour lifting,” capable of establishing key impressions such as “roasted aroma, nut aroma, coffee aroma, cocoa powder feeling, and burnt aroma at the edge of toasted bread” more quickly in the formula (subject to formula verification). At the same time, it is also a nitrogen-containing heterocyclic “building block” used in many fine chemical synthesis and coordination chemistry researches. In many baking/nut/coffee cocoa direction formulas, it is often used for low-ratio bottoming, and the overall cost-performance ratio is usually good (subject to formula verification).
| Item | Specification |
| Product Name | 2,5-Dimethyl Pyrazine |
| CAS No. | 123-32-0 |
| Appearace | Liquid |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
| Melting Point | 15 °C |
| Boiling Point | 155 °C (lit.) |
| Density | 0.99 g/mL at 25 °C (lit.) |
| FEMA & Chemical Name | FEMA 3272 | 2,5-DIMETHYLPYRAZINE |
| Refractive Index | n₂₀/D 1.502 (lit.) |
| Flash Point | 147 °F |
In the field of food flavor, pyrazine compounds are often used to present directions such as baking, roasted nuts, coffee, cocoa, grain roasting, and slight burnt aroma. 2,5-Dimethylpyrazine is especially good at setting up the “roasting base,” turning the formula from “only sweet aroma/vanilla aroma” into “having roasting reality.” Its common implementation scenarios include (but are not limited to):
Coffee and Cocoa Direction: Used to strengthen the bottom support of “roasted bean aroma, coffee powder aroma, cocoa powder aroma.” In some coffee aroma volatile studies, 2,5-Dimethylpyrazine is listed as one of the key pyrazine volatiles, often related to nut and baking-like aromas.
Nut, Peanut, and Grain Baking Direction: Used to enhance the aroma association of “fried peanuts, roasted almonds, roasted hazelnuts, roasted grains.” Relevant research and data compilation generally point out that pyrazines are important aroma contributors in heated/roasted systems, and usually have a strong contribution degree in many thermal processing aromas, so they are often used for low-ratio bottoming; the specific intensity depends on the system and formula structure.
Potato Chip/Baked Potato Direction and Savory Snacks: Used to simulate or strengthen “fried and baked potato chip aroma, roasted potato skin aroma, powdery feeling, and slight nut roasting aroma.” In flavor data, some viewpoints mention that it can be used to enhance the “roasted potato skin-like” breath required by potato chip products, usually requiring high dilution for use.
Meat Aroma and Compound Savory Systems (Soup Bases, Sauces, Puffed Snacks, Compound Seasoning Powders): Under the premise of reasonable dilution and controlled proportion, it is often used to make up for the “roasting edge, slight burnt aroma, nut baking feeling” for savory systems, making the aroma more like real food after heating.
Many purchasers ask: “Why is it that also for making roasting aroma, some formulas smell like essence, while some formulas smell like food?” The key difference often lies in whether the “skeleton taste of thermal reaction” is completed. 2,5-Dimethylpyrazine often assumes this role.
In fragrance and daily chemical retention systems, 2,5-Dimethylpyrazine is not equivalent to “sweet aroma”; it is more like a “texture regulator“: making the aroma change from thin sweetness to a warm breath that is more like roasted nuts, cocoa powder, and coffee roasting. You will find it easier to use in the following themes:
Gourmand and Baking Themes: For example, cocoa, coffee, nut, caramel baking feeling (more towards “roasted aroma” rather than “sugar sweet”).
“Bottom Roasting Support” of Fragrance Products: When there are elements such as vanilla, milk feeling, and cocoa in the formula, a small amount of pyrazines can make the whole more three-dimensional and more durable to smell.
In addition to flavor and fragrance, 2,5-Dimethylpyrazine, as a nitrogen-containing heterocyclic compound, is also often used in scientific research and fine chemical synthesis work, serving as a structural fragment or one of the starting materials. Some data also mention its expansion value in aspects such as coordination chemistry and coordination polymers/functional coordination materials research.
In many baking/nut/cocoa coffee direction formulas, it is often used as a base note skeleton at a lower ratio (subject to small-scale test). Therefore, it frequently appears in formulas at a lower proportion, but has a significant impact on the aroma contour, being especially helpful for the contour establishment of “nut baking, grain roasting, coffee cocoa powder feeling.”
It can enter dessert baking themes, and can also enter savory snacks, sauces, soup bases, and other directions; and it can be used in combination with multiple types of fragrance bases (such as cocoa, nut, milk aroma, burnt aroma, and other bottom aromas) to make the aroma more layered. Its use as “a flavor raw material for nut and beverage flavor blending” is also directly described in the data.
For purchasers, what really matters is: the odor performance and key impurities of every arrival batch cannot drift. As a monomer with a clear structure (or supplied in the form of an isomer mixture), 2,5-Dimethylpyrazine can usually be managed for purity and isomer ratio through GC and other methods, and is subject to the mutually confirmed inspection items and arrival batch reports; in commodity catalogs, it is also common to see specifications given by GC purity.
A: Common descriptions concentrate on the line of roasting nuts, coffee, cocoa, potato/potato chip type roasting feeling, and slight “potato skin-like/wet grain-like/slight bran-like” bottom taste. In coffee aroma research, it is identified as one of the components related to “roasted coffee aroma”; in the summary data of pyrazines, it is also often classified into the “nut baking, roasting type” odor family.
A: This is usually not a single problem of “good or bad raw material,” but formula balance: 2,5-Dimethylpyrazine is responsible for the “roasting skeleton.” If the formula lacks sweet aroma, milk feeling, cocoa type, or fatty aroma to support it, it may make the powdery feeling too heavy and the potato skin-like breath too prominent. A more stable approach is to treat it as a “bottom contour line” and use other raw materials to supplement the “main body food sense.” Pyrazines themselves often appear as key aroma contributors in thermal processing systems, so their presence will be relatively strong.
A: Common reasons include: different labeled pressure conditions, data sources using estimated values or measured values, and some commercial goods may contain a small amount of isomers, etc. When purchasing, it is not necessary to stare at only one number. It is more recommended to confirm: do you want a “purer 2,5-monomer” or a “grade allowing coexistence of certain isomers,” and make the final judgment with GC chromatograms and sensory small-scale tests.
A: The more stable industrial practice is usually to pre-dilute first and then enter the system: first use solvents compatible with the system such as ethanol, propylene glycol, or dipropylene glycol to make a certain proportion of pre-dilution, and then add it according to the process node. Data have descriptions of its solubility with water, ethanol, ether, etc., from different angles; but regardless of which system, pre-dilution can significantly reduce the problem of odor sharpness caused by local over-concentration.
A: It is recommended to focus on three points:
Avoid heat sources and fire sources: Its common flash point data is about 63–64 °C. It is more secure to manage it as a flammable liquid in the factory.
Sealed and moisture-proof: Sealed and dry preservation is recommended; some supplier data suggest it has hygroscopicity and recommend inert gas protection preservation (evaluate comprehensively based on your storage conditions and turnover cycle).
Possibility of low-temperature crystallization/thickening: The melting point is about 15 °C. Physical property changes may occur when the ambient temperature is low; in most cases, it can recover after re-warming and mixing thoroughly. If it is still abnormal, it is recommended to review the appearance and key indicators.
A: Looking only at purity is often not enough. We suggest including at least the following points in the acceptance points:
GC Purity/Main Peak Content (many commodity specifications will give GC indicators)
Isomer Situation (whether 2,6- and other isomers are allowed to coexist)
Color and Odor Consistency (colorless to pale yellow, whether roasting nut coffee characteristics are stable)
Moisture and Volatile Impurities Control (directly affecting storage stability and odor purity, especially important for fragrance customers)
A: In many baking theme formulas, it is often used for roasting skeleton bottoming in the middle and back sections: not pursuing high-pitched front-end impact, but making the whole more like the bottom aroma of real food after heating. Its identification as a related component in the aroma research of heated systems like coffee also indicates that it may be related to “typical odors formed during the baking process.” The actual retention time still depends on the carrier, encapsulation/emulsification method, formula volatility gradient, and packaging barrier.
A: Based on our daily service experience, what purchasers truly need is “implementable, acceptable, and repurchaseable.” Usually, we will provide support around these points:
Sample and Retention Mechanism: Ensure the continuity of your laboratory re-testing and compounding verification.
Batch Documents and Testing Support: Provide testing data bound to the batch, and supplement key impurity attention points (such as isomers and odor consistency) according to needs.
Packaging Specifications Options: From laboratory small packages to factory scale-up packages, reducing your inventory pressure during the switching phase.
Stable Supply and Stocking Advice: Make production scheduling and arrival plans in advance for seasonal products (such as winter hot drinks, baking themes) to avoid shortages in the peak season affecting the launch rhythm.
PubChem Compound Summary: 2,5-Dimethylpyrazine
NIST Standard Reference Data – 2,5-Dimethylpyrazine
References & Data Sources: Physical constants and sensory profiles cited in this guide are based on data from NIST, PubChem, and The Good Scents Company. Regulatory compliance information refers to FEMA and JECFA standards. For specific batch data, please refer to the Certificate of Analysis (COA) provided with the shipment.
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