2-Bromo-4-fluoroaniline (CAS 1003-98-1) Supplier | High Purity | SD Look Chem
2-Bromo-4-Fluoroaniline CAS 1003-98-1 | Organic Raw Materials
-
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
-
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
-
Min: 10 Gram
-
Delivery: 7 Days
-
Transporta: Ocean, Land,Air, DHL，TNT
-
Port: Shanghai Port, Qingdao Port
Name: 2-Bromo-4-Fluoroaniline
CAS: 1003-98-1
Purity: 99%min
MOQ: 1KG
Chemical Structure
Basic Info:
| CAS No: | 1003-98-1 |
| Name: | 2-Bromo-4-Fluoroaniline |
| EINECS: | 619-469-3 |
| Formula: | C6H5BrFN |
| Weight: | 190.01 |
| Other Names: | 2-Bromo-2′-chloroacetophenone |
| Type: | Organic Raw Materials |
| Shelf Life: | 1 years |
| Brand Name: | Look Chem |
| Place of Origin: | Shandong, China |
Basic Introduction to 2-Bromo-4-Fluoroaniline
2-Bromo-4-fluoroaniline (IUPAC Name: 2-bromo-4-fluorobenzenamine, CAS No. 1003-98-1) is a specialized halogenated aromatic amine presented as a low-melting crystalline solid or off-white to light brown fused mass. Featuring both bromine and fluorine substituents arranged orthomorphically and paramorphically to a primary amino functional group, this compound exhibits high regioselectivity in transition-metal-catalyzed cross-coupling and nucleophilic substitution reactions.
To address the stringent requirements of international life science and specialty chemical manufacturers, Shandong Look Chemical Co., Ltd. supplies premium-grade 2-Bromo-4-fluoroaniline engineered for consistent reaction yields. The presence of both bromine (a versatile leaving group for Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira couplings) and fluorine (essential for enhancing lipophilicity and metabolic stability in bioactive molecules) makes it a critical synthon in custom pharmaceutical synthesis, fluorinated agrochemical development, and advanced functional materials.
Nature and Specifications:
Specification
Specification
| Item | Specification |
| Product Name | 2-Bromo-4-Fluoroaniline |
| CAS No. | 1003-98-1 |
| Appearance | Yellow Brown Liquid |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
Product Packaging
2-Bromo-4-Fluoroaniline Application
The unique structural arrangement of 2-Bromo-4-fluoroaniline provides multiple reactive handles for complex organic transformations across key technical sectors:
A. Pharmaceutical Synthesis & Drug Discovery
Kinase & Receptor Inhibitor Precursor: Serves as a fundamental building block in synthesizing nitrogen-containing heterocycles (such as indoles, quinazolines, and benzimidazoles) utilized in small-molecule targeted therapies for oncology and inflammatory disorders.
Fluorine Functionalization: The aromatic fluorine atom imparts metabolic resistance against cytochrome P450 oxidation, improving oral bioavailability and lipophilicity in novel candidate drugs.
B. Agrochemical & Crop Protection Formulations
Fungicide & Herbicide Synthesis: Used in synthesizing broad-spectrum fluorinated fungicides, insecticides, and selective herbicides where halogenated aromatic rings enhance bio-efficacy and environmental persistence.
Custom Heterocyclic Building Block: Acts as a versatile precursor for triazole and pyrazole crop protection agents requiring regioselective halogen substitution.
C. Fine Chemicals & Optoelectronic Materials
Transition-Metal Catalyzed Coupling: The C–Br bond undergoes facile palladium- or copper-catalyzed cross-coupling reactions (e.g., C–N, C–C, and C–S bond formations) to yield substituted aromatic amines.
Functional Polymer & Dye Intermediates: Used as a monomer component or intermediate in developing specialized fluorinated polymers, electronic chemicals, and organic photo-conductive materials.
Certifications & Regulatory Compliance
Navigating international trade compliance and hazardous chemical logistics requires complete transparency. SD Look Chemical operates strictly under certified manufacturing, environmental, and transportation safety standards:
ISO 9001:2015 Quality Management System Certification: Certified production pathways ensuring batch-to-batch reproducibility, strict impurity profiling, and full traceability.
ISO 14001:2015 Environmental Management System Certification: Adherence to sustainable chemical synthesis practices, VOC recovery, and compliant effluent treatment protocols.
GHS & Global SDS Compliance: Fully compliant 16-section Safety Data Sheets aligned with the UN Globally Harmonized System, available in English, German, French, and Japanese for international customs clearance.
REACH Compliance Support: Complete technical documentation, technical dossiers, and regulatory data packages provided to facilitate importation into European Single Market territories.
UN Dangerous Goods (DG) Packaging Certification: Approved packaging protocols utilizing UN-rated fiber drums or sealed fluorinated drums to prevent atmospheric moisture absorption and volatile leakage during ocean and air freight.
To eliminate batch variation and protect client production schedules from raw material defects, every production lot of 2-Bromo-4-fluoroaniline undergoes rigorous multi-stage analytical testing in our Jinan and Ningxia testing centers prior to dispatch.
Typical Certificate of Analysis (COA) Specifications:
Appearance: Off-white to light brown crystalline low-melting solid (Conforms / Visual Inspection)
Purity / Assay (GC-FID): ≥ 99.0 % (Typical Batch Result: 99.42 %)
Melting Point Range: 40.0 °C – 44.0 °C (Conforms / Automatic Melting Point Apparatus)
Moisture Content (Karl Fischer): ≤ 0.30 % (Typical Batch Result: 0.12 %)
Individual Organic Impurity: ≤ 0.30 % (Conforms / GC-FID)
Total Related Organic Impurities: ≤ 1.0 % (Conforms / GC-FID)
Heavy Metal Residue (as Pb): ≤ 10 ppm (Conforms / ICP-MS)
Gas Chromatography with Flame Ionization Detection (GC-FID): Quantitative purity screening to measure primary assay and strictly limit regioisomeric impurities (such as 2-bromo-5-fluoroaniline or 4-fluoroaniline residues).
Karl Fischer Coulometric Titration: Precise moisture measurement to ensure low water content, preventing hydrolysis or catalyst poisoning during water-sensitive organometallic coupling reactions.
Inductively Coupled Plasma Mass Spectrometry (ICP-MS): Trace inorganic metal screening ensures background metallic impurities remain well below acceptable limits for pharmaceutical-grade intermediates.
Controlled Climate Sample Retention: Every dispatched lot is backed by dual 24-month retained samples stored under climate-monitored conditions for full post-delivery audit capabilities.
FAQ
A: Our standard commercial grade offers an assay purity of ≥99.0% by GC. For high-precision pharmaceutical research or specialized fine chemical applications, our analytical team in Jinan can provide customized analytical testing and tighter control on specific isomeric impurities or moisture thresholds upon technical agreement.
A: Like many halogenated aromatic amines, 2-Bromo-4-fluoroaniline is sensitive to light and air exposure, which may cause gradual surface discoloration. It should be stored in tightly sealed, light-resistant containers under an inert atmosphere (such as nitrogen) in a cool, dry, well-ventilated warehouse maintained below 25 °C.
A: Yes. We support customer R&D and process validation by offering sample sizes ranging from 50g to 1kg for qualified industrial buyers. We accommodate order scales from 1kg trial packages up to multi-ton commercial bulk shipments.
A: Every shipment includes a lot-specific Certificate of Analysis (COA), GHS-compliant Safety Data Sheet (SDS), and Commercial Invoice/Packing List. For international sea or air transport, we supply complete Dangerous Goods (DG) packaging documentation and UN transport declarations to ensure compliant customs clearance.
Related References:
Pubchem–2-Bromo-4-Fluoroaniline
2-Bromo-4-Fluoroaniline Manufacturer & Supplier
As an experienced producer and supplier of 2-Bromo-4-Fluoroaniline, Look Chemical is committed to producing and selling high-quality products.
We cooperate and trade with over 6000 factories worldwide, and our high-quality products and services have earned us a high reputation internationally.
As a supplier of 2-Bromo-4-Fluoroaniline, Look Chemical provides supply chain solutions to partners and customers in various industries. We offer highly competitive prices and high-quality products.
If you have a demand for this product, please contact our sales staff and we will provide you with a solution as soon as possible.
Achievements📝
I’m william, CEO of Look Chemical Co, Ltd. Welcome to visit our company. As China’s top Global Supply Specialist of chemicals, we have always been adhering to the principle of “service first, quality first, mutual benefit”, and we insist on Create value for customers and grow together with customers.
In the past few years , we have provided efficient and satisfactory services to more than 6000 customers and have been widely praised internationally. In the future, we will strive to provide more than 100,000 customers with professional and thoughtful services, and strive to become your first choice for worry-free purchasing chemicals in China , Hope to bring you a good cooperation experience. If you have any questions, please feel free to contact us.
Pre-Sales Service👍
* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.
* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
After-Sales Service🔔
*We will monitor the logistics information in real time and will share the information with you.
* You can consult us at any time if you have any questions about the product, and we will answer you in time.
*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.
Advice on Shipping✈️
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Look chemical company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 30,000 products with the best quality and competitive price to meet your different purchasing needs.
Product Data:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Analysis (MOA)
- Nuclear Magnetic Resonance (NMR)
- Packing pictures and loading video before loading
- Free Sample
- Factory audit
