Nicotinamide Riboside Chloride (NRC)-Excellent NMN Alternatives

The Most Cost-Effective Anti-Aging Products Nicotinamide Riboside Chloride

• Appearance: White to off-white powder

• Purity: 98%min(HPLC)

• Solubility: Soluble to 100 mM in DMSO and to 100 mM in water

Introduction:

Nicotinamide Riboside Chloride(NRC) is the precursor of nicotinamide adenine dinucleotide (NAD) and represents a source of vitamin B3. Recent studies have shown that ingesting a larger amount of Nicotinamide Riboside Chloride than naturally occurring in foods can give Chemicalbook new health benefits. Nicotinamide mononucleotide plays an important role in the energy production of human cells. It is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).

Anti-aging mechanism, comparison between NRC and NMN:

1. NRC anti-aging mechanism：

Nicotinamide Riboside Chloride（NRC） has been involved in increasing tissue NAD concentration and inducing insulin sensitivity as well as enhancing deacetylase (sirtuin) function. Its ability to increase NAD production indicates that Nicotinamide Riboside Chloride can also improve mitochondrial health, stimulate mitochondrial function and induce the production of new mitochondria. Other studies using Nicotinamide Riboside Chloride in Alzheimer’s disease models have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating the synthesis of NAD in the brain. In addition, a 2012 study observed that mice on a high-fat diet supplemented with nicotinamide riboside Chemicalbook had a 60% reduction in weight gain compared with mice on the same high-fat diet without Nicotinamide Riboside Chloride. Nicotinamide riboside chloride (3-carbamoyl-1-[(2R,3R,4S5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-yl]-pyridine -1-Onium chloride; also known as 1-(β-D-ribofuranosyl)nicotinamide chloride) is a known salt form of Nicotinamide Riboside Chloride, despite the usefulness of nicotinamide riboside and its chloride salt Properties (for example, in medicines or nutritional supplements), but usually need improvement.

2. NMN anti-aging mechanism

β-nicotinamide mononucleotide(NMN) is the precursor substance of the cofactor NAD+ of longevity protein in human body. NAD+ is an important coenzyme of the tricarboxylic acid cycle, which promotes the metabolism of sugars, fats and amino acids, and participates in the synthesis of energy; NAD+ is the only substrate of coenzyme I depleting enzymes (the only substrate of DNA repair enzyme PARP, longevity protein Sirtuins Chemicalbook The only substrate, the only substrate of cyclic ADP ribose synthase CD38/157). NAD+ participates in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism will not work. Elderly people lack NAD+, so all kinds of big and small problems will come. By supplementing NAD+, you can fully anti-aging.

3. Nicotinamide Riboside Chloride(NRC) and NMN anti-aging comparison

Both NRC and NMN play an anti-aging effect by acting on NAD, and their mechanism of action is basically the same, and their effects are similar. According to the experimental data and the long-term anti-aging effect, NRC is obviously better than NMN! In addition, the price-performance ratio compares Nicotinamide Riboside Chloride with more advantages than NMN!

References

“Nicotinamide riboside”. pubchem.ncbi.nlm.nih.gov.

“Spherix/ChromaDex GRAS submission” (PDF). FDA.gov. Retrieved 18 February 2019.

Wikipedia