Creatine, in biochemistry, is a nitrogen-containing organic acid found naturally in vertebrates that helps provide energy for muscles and nerve cells. Creatine was first discovered in skeletal muscles in 1832 by Michel Eugene Schaeffler and renamed “creatine” after the Greek “κρέας” (kreas, meat).
Creatine is interconverted with creatine phosphate and thus can be part of an arginine – and arginine phosphate – based system that operates in many invertebrates. Because of this energy transporter, the ratio of ATP to ADP is maintained at a high level. This ensures a high level of free energy in ATP and minimizes the loss of adenosine, which can cause cellular dysfunction. Such a high – energy phosphate buffer solution is also known as prophosphate.
Creatine and the treatment of muscle diseases
Two scientific studies have shown that creatine may be beneficial for neuromuscular disorders. First, M. Flint Beal of Cornell University Medical Center, an MDA-sponsored researcher, showed that creatine was twice as effective as riluzole, a current prescription drug, in extending liver life in rats with ALS. He also believes that creatine has a neuroprotective effect on rats with ALS because it increases the energy available to damaged nerve cells and blocks chemical pathways that lead to cell death.
Second, a study by Mark Tarnopolsky and Joan Martin, two Canadian researchers at McMaster University Medical Centre, found that creatine gave people with a variety of neuromuscular disorders modest gains in strength. The latest paper was published in the March 1999 issue of neurology.
Application in fitness
Arguably, the most common use of creatine in daily life is as a training supplement for bodybuilders. Professional and semi-professional bodybuilders take a dose of creatine to help their muscles grow and improve their quality.
In most cases, the ideal time to take creatine is half an hour before and half an hour after a workout.
If you do not have a heavy load of strength training, you can take it at noon.
Creatine usage is calculated based on body weight. Normal daily supplements are 0.7 to 1.2 mg for men and 0.5 to 1.0 mg for women who do not participate in heavy exercise.
So far no reliable evidence has been found that taking additional creatine has any serious side effects, as it is one of the substances produced by the body. It can cause mild diarrhea if used in excess. There are still side effects, so don’t eat them.
March 2015. A study published in the British Journal of Cancer found that men who use supplements containing creatine may have a higher risk of testicular Cancer.