Application of Chlorhexidine digluconate

Pharmacological action

Chlorhexidine digluconate is a cationic surface active preservative with a broad-spectrum antibacterial effect. The mechanism of action is to change the permeability of the bacterial cell membrane. It is a disinfectant and antiseptic. Certain Staphylococcus, Streptococcus mutans, Streptococcus salivarius, Candida albicans, Escherichia coli and anaerobic propionic acid bacteria are highly sensitive to it, Streptococcus haemophilus is moderately sensitive, Proteus, Pseudomonas, Klebsiella Chemicalbook and Gram-negative cocci (such as Villonococcus) are low-sensitive. Its antibacterial effect on Gram-positive and negative bacteria is stronger than disinfectants such as benzalkonium bromide. This product is still effective in the presence of serum, blood, etc. The mechanism of action of this product is to adsorb on the osmotic barrier of the bacterial cytoplasmic membrane, allowing the cell contents to leak out and exert an antibacterial effect. Low concentration has antibacterial effect, high concentration has bactericidal effect.

Product Usage

Disinfectant and antiseptic, have a fairly strong broad-spectrum antibacterial and bactericidal effect, and have the ability to kill both gram-positive bacteria and gram-negative bacteria. It is widely used for skin disinfection, surgical disinfection, instrument disinfection and washing wounds, bladder lavage burns, burns, oral cavity anti-inflammatory, sore healing, and abdominal cavity and intestinal mucosal disinfection during surgery, etc. It is also used for tableware, vegetables and fruits in daily life. , Drinking water disinfection. Clinically, it is often formulated into an aqueous solution of chlorhexidine gluconate for various purposes of disinfection.

How to use Chlorhexidine gluconate is often used in a formula with other disinfectants. The specific formula, usage and dosage should be determined according to the equipment and the experimental results. When used as a disinfectant alone, it is recommended to prepare a 2% aqueous solution. Packing and storage Store in a cool, ventilated warehouse. The storage temperature should not exceed 37℃. It should be stored separately from oxidants and edible chemicals, and avoid mixed storage and keep the container tightly closed. Keep away from fire and heat sources. The warehouse must be equipped with lightning protection equipment. The exhaust system should be equipped with a grounding device to remove static electricity. Use explosion-proof lighting and ventilation settings. It is forbidden to use equipment and tools that are prone to sparks. The storage area should be equipped with leakage emergency treatment equipment and suitable storage materials.

1. In the application of mouthwash

Purchase product: 2 tons of chlorhexidine gluconate (T)

Purpose: To prevent oral infections in patients with weakened immunity, and to treat gingivitis and periodontal diseases.

Function: Mouthwash produced by a mouthwash brand in Shandong contains 0.12% chlorhexidine, with an oral bacteriostatic rate of 99.99%; it effectively removes peculiar smell, prevents oral diseases, and maintains oral hygiene.

Note: Please consult our technical staff for its pharmacological effects and dosage ratio

2. Application in antiseptic hand sanitizer

Purpose: As a sterilization and disinfection hand sanitizer for medical staff, it can quickly kill bacteria and have a durable antibacterial effect.

Conclusion: A Zhejiang Biotechnology Co., Ltd. uses this product to develop a disinfectant hand sanitizer, which is a hand sanitizer disinfectant product used under specific conditions such as surgery and blood draw. This type of product basically does not add anionic surfactants, and is mainly caused by sterilization. Effective composition of chlorhexidine gluconate and additives.