5-Chloro-8-Hydroxyquinoline (CAS 130-16-5): Sourcing Guide for Research and Industrial Buyers

5-Chloro-8-Hydroxyquinoline

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5-Chloro-8-Hydroxyquinoline (CAS 130-16-5) is a halogenated hydroxyquinoline derivative primarily known as a metal chelating agent and antimicrobial compound. The 8-hydroxyquinoline scaffold gives it the ability to form stable complexes with a range of transition metals, while the chloro substitution at the 5-position modifies both the electronic character and biological activity relative to the parent 8-hydroxyquinoline.
 
Buyers approaching this compound for the first time are usually coming from one of three directions: antifungal research, metal ion coordination chemistry, or as an intermediate for pharmaceutical synthesis. Each application has its own specification requirements, and they are not interchangeable.

Where Specification Gaps Actually Appear 

The most common sourcing problem with 5-Chloro-8-Hydroxyquinoline is not low purity — it is the failure to specify which impurities matter for your application. The compound can be synthesized through several routes, and the residual impurity profile differs by route. For a researcher using it as a metal chelation standard, minor organic impurities at 0.2% are irrelevant. For a pharmaceutical synthesis step where this is a precursor to a regulated API, those same impurities may require specific identification and limits.
 
Ask suppliers directly: what is the synthesis route, and what are the three most likely process-related impurities? A competent manufacturer will answer this without hesitation.

Physical Form and Handling

5-Chloro-8-Hydroxyquinoline is a solid at ambient temperature, typically presenting as a light yellow to tan crystalline powder with a melting point in the range of 130 to 134°C. It is sensitive to prolonged light exposure — store in amber containers or dark packaging if your application requires stability over months rather than days. Solubility in water is low; it dissolves more readily in ethanol, acetone, and other common organic solvents, which is relevant if your application involves solution preparation.
 
Do not let the compound sit in open containers. Moisture uptake changes weight-based purity calculations in ways that matter when you are weighing out precise quantities for laboratory work.

Regulatory Considerations

5-Chloro-8-Hydroxyquinoline is not a controlled substance under UN schedules and does not appear on major restricted chemical lists for standard industrial commerce. However, certain markets have specific import documentation requirements for halogenated organic compounds. Verify the IATA/IMDG classification for your shipping mode and confirm whether your destination country requires any pre-import notification.
 
sdlookchem’s export team routinely handles these requirements and can assist with documentation.
5-Chloro-8-Hydroxyquinoline

What sdlookchem Provides

Shandong Lookchemical manufactures 5-Chloro-8-Hydroxyquinoline (CAS 130-16-5) with in-house quality control covering melting point confirmation, HPLC purity, and identity by NMR or IR. Documentation provided with each commercial batch includes a batch-specific Certificate of Analysis, a current GHS Safety Data Sheet, and complete export documents.
 
Minimum order quantity is 1 kg. Larger quantities priced on request. Lead time is typically 5 to 10 business days for standard orders. Packaging in amber glass bottles for laboratory quantities; fiber drums with moisture barrier liner for bulk quantities.
 
For pricing and specification questions, contact sales01@sdlookchemical.com. Technical data and SDS available on request.
 

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